Am J Clin Nutr:出生后6个月内纯母乳喂养可降低婴儿肠道病原体入侵的风险

2021-12-04 Nebula MedSci原创

纯母乳喂养与出生后六个月检测出4种重要肠道病原体的可能性较低有关

众所周知,母乳喂养可以降低肠道病原体感染的风险,但对特定肠道病原体的保护还没有很好地描述。

本研究旨在评估纯母乳喂养(纯母乳喂养或非营养液体喂养的天数)与肠道病原体检测之间的关联。

从8个地点招募了2145名新生儿,其中1712名在6个月内为母乳喂养,且有关键的肠道病原体数据。本研究专注于十一种肠道病原体:腺病毒 40/41、诺如病毒、萨波病毒、星状病毒和轮状病毒、产肠毒素大肠杆菌 (ETEC)、弯曲杆菌属和经典肠致病性大肠杆菌,以及肠道聚集性大肠杆菌、志贺氏菌和隐孢子虫。采用Logistic 回归估计粪便中肠道病原体检测的风险,并使用生存分析来估计首次检测到肠道病原体的时间。

不同母乳喂养组,不同肠道病原体检出的优势比

在取粪便样本前30天内,纯母乳喂养的天数增加10%的婴儿的粪便中检测到三种大肠杆菌和弯曲杆菌属的可能性较小(平均优势 0.92-0.99),但检出病毒病原体的可能性相似(0.99-1.02)。从出生后纯母乳喂养的时间长10%即与首次检出三种大肠杆菌、弯曲杆菌、腺病毒、星状病毒和轮状病毒的时间延迟有关(平均风险比 0.52-0.75)。但3个月时的差异无统计学差异。

综上,在这项大型多中心队列研究中,纯母乳喂养与出生后六个月检测出4种重要肠道病原体的可能性较低有关。该研究结果还表明,纯母乳喂养与粪便中某些细菌和病毒病原体的首次检出时间延迟有关。由于这些病原体中的一部分是儿童期发育不良的危险因素,因此这项研究强调了出生后六个月内进行纯母乳喂养以优化早期健康的重要性。

原始出处:

McCormick Benjamin J J,Richard Stephanie A,Murray-Kolb Laura E et al. Full breastfeeding protection against common enteric bacteria and viruses: Results from the MAL-ED cohort study.[J] .Am J Clin Nutr, 2021, https://doi.org/10.1093/ajcn/nqab391

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    2022-02-16 ms6000001322083058

    学习

    0

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    2021-12-23 bibibinaomi

    应该得到普及

    0

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    2021-12-06 villahu
  5. [GetPortalCommentsPageByObjectIdResponse(id=1194005, encodeId=246f11940052b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa4e6501784, createdName=ms6000001322083058, createdTime=Wed Feb 16 12:56:41 CST 2022, time=2022-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665114, encodeId=07071665114e2, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Sun Jul 31 14:49:01 CST 2022, time=2022-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1083488, encodeId=504b108348867, content=应该得到普及, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211020/a19177b4a76046de8f46d357087a3921/6d4b4136268541f5a299525fe3ea791b.jpg, createdBy=49365641474, createdName=bibibinaomi, createdTime=Thu Dec 23 10:26:17 CST 2021, time=2021-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299645, encodeId=2c94129964588, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Mon Dec 06 13:49:01 CST 2021, time=2021-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510671, encodeId=dc6115106e119, content=<a href='/topic/show?id=2efbe0807b1' target=_blank style='color:#2F92EE;'>#病原体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70807, encryptionId=2efbe0807b1, topicName=病原体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6c210226313, createdName=xue8605, createdTime=Mon Dec 06 13:49:01 CST 2021, time=2021-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077241, encodeId=866b10e724196, content=帅气, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210906/e141ddca670e4042bffbf47e00f8d2fd/b6517df71dfe42cb979aacdc454225cc.jpg, createdBy=0c532181739, createdName=穆新, createdTime=Mon Dec 06 08:20:11 CST 2021, time=2021-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077150, encodeId=b15f10e71509c, content=非常好的课程, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dd85589660, createdName=ms1000000798193302, createdTime=Sun Dec 05 21:15:38 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076987, encodeId=762d10e698733, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/20/44e485222679b3a7b0d5676ca7443126.jpg, createdBy=ef735089224, createdName=随风1991, createdTime=Sun Dec 05 08:00:38 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076984, encodeId=c03d10e6984ce, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Sun Dec 05 07:57:48 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
    2021-12-06 xue8605
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    2021-12-06 穆新

    帅气

    0

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    2021-12-05 ms1000000798193302

    非常好的课程

    0

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    2021-12-05 随风1991

    非常棒

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1194005, encodeId=246f11940052b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa4e6501784, createdName=ms6000001322083058, createdTime=Wed Feb 16 12:56:41 CST 2022, time=2022-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665114, encodeId=07071665114e2, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Sun Jul 31 14:49:01 CST 2022, time=2022-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1083488, encodeId=504b108348867, content=应该得到普及, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211020/a19177b4a76046de8f46d357087a3921/6d4b4136268541f5a299525fe3ea791b.jpg, createdBy=49365641474, createdName=bibibinaomi, createdTime=Thu Dec 23 10:26:17 CST 2021, time=2021-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299645, encodeId=2c94129964588, content=<a href='/topic/show?id=7a056349485' target=_blank style='color:#2F92EE;'>#母乳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63494, encryptionId=7a056349485, topicName=母乳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf1b289, createdName=villahu, createdTime=Mon Dec 06 13:49:01 CST 2021, time=2021-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510671, encodeId=dc6115106e119, content=<a href='/topic/show?id=2efbe0807b1' target=_blank style='color:#2F92EE;'>#病原体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70807, encryptionId=2efbe0807b1, topicName=病原体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6c210226313, createdName=xue8605, createdTime=Mon Dec 06 13:49:01 CST 2021, time=2021-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077241, encodeId=866b10e724196, content=帅气, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210906/e141ddca670e4042bffbf47e00f8d2fd/b6517df71dfe42cb979aacdc454225cc.jpg, createdBy=0c532181739, createdName=穆新, createdTime=Mon Dec 06 08:20:11 CST 2021, time=2021-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077150, encodeId=b15f10e71509c, content=非常好的课程, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dd85589660, createdName=ms1000000798193302, createdTime=Sun Dec 05 21:15:38 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076987, encodeId=762d10e698733, content=非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/20/44e485222679b3a7b0d5676ca7443126.jpg, createdBy=ef735089224, createdName=随风1991, createdTime=Sun Dec 05 08:00:38 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076984, encodeId=c03d10e6984ce, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Sun Dec 05 07:57:48 CST 2021, time=2021-12-05, status=1, ipAttribution=)]
    2021-12-05 仁术2021

    不错,学习了。

    0

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