Mov Disord:根除幽门螺旋杆菌是否可改善帕金森病患者的运动功能?

2021-07-21 MedSci原创 MedSci原创

幽门螺旋杆菌(HP)感染与帕金森病(PD)的运动功能恶化有关。近日,一项平行组、双盲、随机安慰剂对照的单中心试验评估了根除HP对PD症状的影响,研究结果已发表于Mov Disord。

幽门螺旋杆菌(HP)感染与帕金森病(PD)的运动功能恶化有关。近日,一项平行组、双盲、随机安慰剂对照的单中心试验评估了根除HP对PD症状的影响,研究结果已发表于Mov Disord。

将HP尿素呼吸试验和血清学阳性的PD患者随机(1:1)分组:接受标准根除三联疗法或安慰剂,为期1周。在第6、12、24和52周评估预先指定的运动、非运动和生活质量结果。主要结果是ON药物MDS-UPDRS运动评分的基线至第12周的变化。在基线时进行乳糖-氢气呼气试验,以检测合并的小肠细菌过度生长,并在第24周重复,同时进行尿素呼气试验。

 

结果,共有310名患者被筛选为合格者,80人被随机分组,其中67人被纳入全面分析组(32名治疗组患者,35名安慰剂患者)。在第12周,根除HP并没有改善MDS-UPDRS运动评分(与安慰剂相比,平均差异为 2.6 分,95% 置信区间:-0.4 至 5.6,P = 0.089)。在第12周和第52周,任何运动、非运动或生活质量方面的结果都没有明显改善。全面分析和按方案分析(基于根除状态)都支持这些结论。小肠细菌过度生长状态并不影响治疗结果。

综上,根除HP并不能改善PD的临床结果,表明没有理由以改善PD症状为目标进行常规HP筛查或根除。

 

原始出处:

 

Ai Huey Tan, et al., Helicobacter pylori Eradication in Parkinson's Disease: A Randomized Placebo-Controlled Trial. Mov Disord. 2020 Dec;35(12):2250-2260. doi: 10.1002/mds.28248.

 

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    2022-01-18 cmsvly
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    2021-09-08 cmj8wellington
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    2022-05-22 风铃830
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