综述:Copeptin——新的急性心肌梗死和脑卒中Biomarker

2011-12-06 MedSci原创 MedSci原创

Copeptin是下丘脑和垂体合成和释放的一种神经肽,它由39个氨基酸残基所组成,是抗利尿激素前体的一种C-末端肽(Pro- Vasopressin 126-164),亦称为CT-Pre AVP。近年来发现,Copeptin是一种较脑钠素(BNP/NT-PreBNP)、心肌肌钙蛋白(cTnT)等心血管标志物更为敏感、精确的诊断急性心肌梗、急性冠动脉综合症、脑卒中和心功能不全发生和预后的新的Biom

Copeptin是下丘脑和垂体合成和释放的一种神经肽,它由39个氨基酸残基所组成,是抗利尿激素前体的一种C-末端肽(Pro- Vasopressin 126-164),亦称为CT-Pre AVP。近年来发现,Copeptin是一种较脑钠素(BNP/NT-PreBNP)、心肌肌钙蛋白(cTnT)等心血管标志物更为敏感、精确的诊断急性心肌梗、急性冠动脉综合症、脑卒中和心功能不全发生和预后的新的Biomarker :在心脑急性事件时,血浆Copeptin水平急剧增加,它较BNP、cTnT等已知Biomarkers的变化,发生的更早、更快、更明显。其血浆 Copeptin升高的浓度越高,心肌梗塞和脑卒中的病变程度亦越严重,预后亦越差,死亡率亦越高。它与BNP 和cTnT联合进行检测,其诊断和预后心脑血管病急性事件的敏感度和准确度将更高,其精确率可达98%以上。因此,Copeptin作为心脑血管病的 Biomarkers越来越受到人们的关注,并逐步为临床所采用。 但是,Copeptin作为一种敏感、精确的Biomarker 还不够成熟,还有一下问题值得我们进一步研究: Copeptin的生理

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    2023-06-13 ms5000001084454211 来自广西

    双阴排除

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    2012-10-29 cqlidoudou
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    2012-11-21 feather89
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    2012-10-19 sunylz
  6. [GetPortalCommentsPageByObjectIdResponse(id=2142603, encodeId=172e2142603ca, content=双阴排除, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d23a5712148, createdName=ms5000001084454211, createdTime=Tue Jun 13 19:01:31 CST 2023, time=2023-06-13, status=1, ipAttribution=广西), GetPortalCommentsPageByObjectIdResponse(id=1907373, encodeId=9272190e3730e, content=<a href='/topic/show?id=835e11305d7' target=_blank style='color:#2F92EE;'>#marker#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11305, encryptionId=835e11305d7, topicName=marker)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Mon Oct 29 02:19:00 CST 2012, time=2012-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2021214, encodeId=d6482021214c4, content=<a href='/topic/show?id=9b0b50920a' target=_blank style='color:#2F92EE;'>#Copeptin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5092, encryptionId=9b0b50920a, topicName=Copeptin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=33b92500139, createdName=12498b37m72暂无昵称, createdTime=Wed Feb 01 05:19:00 CST 2012, time=2012-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725398, encodeId=db7d1e25398cb, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Nov 21 16:19:00 CST 2012, time=2012-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916854, encodeId=a54119168547d, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Oct 19 12:19:00 CST 2012, time=2012-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605314, encodeId=0a601605314fa, content=<a href='/topic/show?id=2df6344ef2' target=_blank style='color:#2F92EE;'>#biomarker#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3447, encryptionId=2df6344ef2, topicName=biomarker)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53c919370539, createdName=1249857fm38暂无昵称, createdTime=Thu Dec 08 13:19:00 CST 2011, time=2011-12-08, status=1, ipAttribution=)]