Dent Mater J:纯钛表面的化学修饰增强人间充质干细胞的细胞相容性和分化

2019-10-11 lishiting MedSci原创

这篇研究的目的是通过生物功能性分子将人骨髓来源的间充质干细胞定植在钛种植体表面,以提高其细胞相容性以及分化。

这篇研究的目的是通过生物功能性分子将人骨髓来源的间充质干细胞定植在钛种植体表面,以提高其细胞相容性以及分化。

研究将Gly-Arg-Gly-Asp-Ser (GRGDS)肽、人血浆纤连蛋白(pFN)或小牛皮来源的I型胶原(Col)共价固定于钛表面。

结果显示,Col和pFN定植于钛表面的细胞黏附数量较多,是粘附于抛光的钛对照表面细胞的2倍。Col和pFN定植于钛表面的细胞ALP活性、矿化结节形成明显高于抛光的对照表面。

这些结果表明,将生物功能性分子定植于钛表面能够增强人骨髓来源间充质干细胞的粘附、扩展、增殖和分化,如:Col和pFN。它可以促进骨和钛种植体的快速整合。

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    2020-01-18 仁心济世
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    2019-10-14 独孤立克

    干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦

    0

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    2019-10-13 zhangyxzsh