Eur Heart J:合并二尖瓣狭窄患者的经导管主动脉瓣置换术

2018-12-29 xiangting MedSci原创

因为严重症状性AS接受TAVR的患者中,约五分之一并发MS,并与1年时心血管不良事件风险升高3倍相关。

接受经导管主动脉瓣置换术(TAVR)的老年患者中,联合瓣膜病变越来越受到关注。这项分析旨在调查合并二尖瓣狭窄(MS)对严重、症状性主动脉瓣狭窄(AS)并接受TAVR治疗患者临床结局的影响。

2007年8月至2015年12月期间接受TAVR的1339名患者中,971名患者(72.5%)有可用足够的超声心动图数据,用于评估MS的严重程度和病因。根据合并MS的程度和病因对患者进行分层。176名TAVR患者(18.1%)记录有二尖瓣狭窄(平均二尖瓣面积1.9±0.4cm2),并且分别在110名(62.5%)和66名(37.5%)患者中被认为是退行性和风湿性的。28名患者(2.9%)的二尖瓣狭窄被分类为中度/重度。伴或不伴MS患者的基线特征相当。1年时,与无MS患者相比,MS患者的心血管死亡 [36(21.4%)vs.66(8.7%);调整后的风险比(HRadj)3.64,95%置信区间(CI)2.38-5.56]和致残性卒中风险升高[12(7.1%)vs.23(3.0%);HRadj 2.98,95%CI 1.46-6.09]。心血管死亡和致残性卒中的差异在相关手术后的30天内出现,并主要由风湿性MS患者的差异驱动[心血管死亡:7(10.6%)vs.24(3.2%),HRadj 4.80,95% CI 1.98-11.6;致残性卒中:4(6.1%)vs.16 (2.0%),HRadj 4.18,95%CI 1.34-13.0]。

因为严重症状性AS接受TAVR的患者中,约五分之一并发MS,并与1年时心血管不良事件风险升高3倍相关。差异出现的早,并主要由风湿性MS患者推动。

原始出处:

Masahiko Asami. Transcatheter aortic valve replacement in patients with concomitant mitral stenosis. Eur Heart J. 28 December 2018.

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createdBy=f1c626846620, createdName=amyloid, createdTime=Mon Aug 26 02:10:00 CST 2019, time=2019-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332597, encodeId=1583133259e27, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Mon Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357050, encodeId=7278135e0504b, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367149, encodeId=80b3136e1490b, content=<a href='/topic/show?id=b6222320322' target=_blank style='color:#2F92EE;'>#主动脉瓣置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23203, encryptionId=b6222320322, topicName=主动脉瓣置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b24249, createdName=medsci246, createdTime=Mon Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415437, encodeId=c4e7141543e97, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Mon Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463223, encodeId=265414632237d, content=<a href='/topic/show?id=cff92389310' target=_blank style='color:#2F92EE;'>#二尖瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23893, encryptionId=cff92389310, topicName=二尖瓣)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fdb26536308, createdName=wwzzly, createdTime=Mon Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510181, encodeId=2008151018108, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e010191378, createdName=lsj631, createdTime=Mon Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536551, encodeId=e770153655182, content=<a href='/topic/show?id=a894e826546' target=_blank style='color:#2F92EE;'>#经导管主动脉瓣置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78265, encryptionId=a894e826546, topicName=经导管主动脉瓣置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b38112697961, createdName=yytms, createdTime=Mon Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563032, encodeId=27b815630322b, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=)]
    2018-12-31 zhaojie88
  5. [GetPortalCommentsPageByObjectIdResponse(id=1742556, encodeId=4a731e425565d, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Tue Feb 19 21:10:00 CST 2019, time=2019-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671800, encodeId=133616e1800eb, content=<a href='/topic/show?id=cb0223906b8' target=_blank style='color:#2F92EE;'>#二尖瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23906, encryptionId=cb0223906b8, topicName=二尖瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1c626846620, createdName=amyloid, createdTime=Mon Aug 26 02:10:00 CST 2019, time=2019-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332597, encodeId=1583133259e27, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Mon Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357050, encodeId=7278135e0504b, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, 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Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563032, encodeId=27b815630322b, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1742556, encodeId=4a731e425565d, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Tue Feb 19 21:10:00 CST 2019, time=2019-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671800, encodeId=133616e1800eb, content=<a href='/topic/show?id=cb0223906b8' target=_blank style='color:#2F92EE;'>#二尖瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23906, encryptionId=cb0223906b8, topicName=二尖瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  7. [GetPortalCommentsPageByObjectIdResponse(id=1742556, encodeId=4a731e425565d, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Tue Feb 19 21:10:00 CST 2019, time=2019-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1671800, encodeId=133616e1800eb, content=<a href='/topic/show?id=cb0223906b8' target=_blank style='color:#2F92EE;'>#二尖瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23906, encryptionId=cb0223906b8, topicName=二尖瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, 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Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563032, encodeId=27b815630322b, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=)]
    2018-12-31 wwzzly
  8. 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Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563032, encodeId=27b815630322b, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Dec 31 06:10:00 CST 2018, time=2018-12-31, status=1, ipAttribution=)]
    2018-12-31 lsj631
  9. 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  10. 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    2018-12-31 slcumt

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