ARD:秋水仙碱预防与 COVID-19 疫苗接种后痛风发作减少有关

2022-03-13 MedSci原创 MedSci原创

COVID-19 疫苗接种与痛风发作的几率增加相关,痛风发作主要发生在每次疫苗接种后的第 1 个月,并且与秋水仙碱预防负相关。

     目标:COVID-19 疫苗接种通常会引发一系列短暂的炎症症状。痛风与几种与 COVID-19 不良结果相关的合并症有关,一些疫苗接种可能会引发痛风发作。研究者分析了用灭活病毒接种COVID-19疫苗后前3个月痛风发作的风险,以及秋水仙碱是否可以预防 COVID-19 疫苗接种后的痛风发作。

     方法:2021 2 月至 2021 10 月在青岛大学附属医院痛风门诊开展了一项基于临床分娩人群的横断面研究。采用系统随机抽样技术在随访痛风患者中选择研究参与者。研究者结合访谈、健康二维码和医疗记录收集数据,包括疫苗接种和潜在风险因素。逻辑回归用于调整协变量。

     结果:研究者招募了 549 名痛风参与者(中位年龄 39 岁,84.2% 接种了疫苗)。在接种 COVID-19 疫苗的 462 名患者中,203 名(43.9%)在接种疫苗后 3 个月内至少出现了一次痛风发作。大多数突发事件发生在第一剂(99/119 (83.2%))或第二剂(70/115 (60.9%))疫苗接种后的 1 个月内。与未接种疫苗的参与者相比,COVID-19 疫苗接种与 3 个月内痛风发作的几率较高相关(调整后的 OR 6.0295%CI 3.00 -12.08)。使用秋水仙碱可使疫苗后痛风发作的可能性降低 47%

    结论:COVID-19 疫苗接种与痛风发作的几率增加相关,痛风发作主要发生在每次疫苗接种后的第 1 个月,并且与秋水仙碱预防负相关。这些发现值得进一步研究 mRNA 疫苗是否具有相同的效果,理想情况下是前瞻性和多中心合作。这项研究可能会为痛风患者提供有关 COVID-19 疫苗接种期间痛风发作风险的信息。 

 

出处:

Lu J, He Y, Terkeltaub R, et al. Colchicine prophylaxis is associated with fewer gout flares after COVID-19 vaccination.Annals of the Rheumatic Diseases Published Online First: 11 March 2022. doi: 10.1136/annrheumdis-2022-222199

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    2022-03-15 xsybjmu

    学习了

    0

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    2022-03-14 医者仁者

    #秋水仙碱#有成为神药的趋势#痛风#

    0

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