Lancet: 恶性疟原虫高分辨地图——2000-2017

2019-06-23 MedSci MedSci原创

恶性疟原虫高分辨地图为全球疟疾控制规划、方案执行和监测提供了一个有力手段

自2000年以来,疟疾控制干预大大降低了全球疟疾的发病率和死亡率,近日研究人员对疟疾发病风险的空间异质模式进行了研究,以更有效的针对负担沉重地区。

研究人员更新和完善了撒哈拉以南非洲地区的恶性疟原虫寄生率和临床发病率模型,采用生态降级方法,通过常规监测获得的疟疾发病率数据进行了寄生虫率和发病率估计。通过高分辨率协变量曲面法,研究人员估计了恶性疟原虫感染率、临床发病率和死亡率在国家、次国家和5×5km范围内的变化。

研究发现2005年至2017年期间全球疟疾负担迅速下降,发病率下降了27.9%,死亡率下降了42.5%。尽管疟疾流行地区的人口不断增加,但从2005年至2017年,恶性疟原虫病例从2.32亿例降至1.93亿例,死亡人数从925800例下降到618700例。尽管全球负担有所下降,但撒哈拉以南非洲地区90.1%的人口继续居住在流行地区,2017年该地区占病例数的79.4%,死亡人数的87.6%。

恶性疟原虫高分辨地图为全球疟疾控制规划、方案执行和监测提供了一个有力手段。

原始出处:


本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1830124, encodeId=fb3b183012438, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Dec 25 02:12:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997611, encodeId=74e0199e6111f, content=<a href='/topic/show?id=e06810222253' target=_blank style='color:#2F92EE;'>#高分辨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102222, encryptionId=e06810222253, topicName=高分辨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Mar 19 14:12:00 CST 2020, time=2020-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387876, encodeId=5dab138e87609, content=<a href='/topic/show?id=25ffe04313d' target=_blank style='color:#2F92EE;'>#疟原虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70431, encryptionId=25ffe04313d, topicName=疟原虫)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e622500011, createdName=12498484m46(暂无昵称), createdTime=Tue Jun 25 00:12:00 CST 2019, time=2019-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578836, encodeId=ac4115e8836b5, content=<a href='/topic/show?id=9b395292257' target=_blank style='color:#2F92EE;'>#恶性疟原虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52922, encryptionId=9b395292257, topicName=恶性疟原虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b5f16444736, createdName=ms6832696159214430, createdTime=Tue Jun 25 00:12:00 CST 2019, time=2019-06-25, status=1, ipAttribution=)]
    2019-12-25 howi
  2. [GetPortalCommentsPageByObjectIdResponse(id=1830124, encodeId=fb3b183012438, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Dec 25 02:12:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997611, encodeId=74e0199e6111f, content=<a href='/topic/show?id=e06810222253' target=_blank style='color:#2F92EE;'>#高分辨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102222, encryptionId=e06810222253, topicName=高分辨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Mar 19 14:12:00 CST 2020, time=2020-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387876, encodeId=5dab138e87609, content=<a href='/topic/show?id=25ffe04313d' target=_blank style='color:#2F92EE;'>#疟原虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70431, encryptionId=25ffe04313d, topicName=疟原虫)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e622500011, createdName=12498484m46(暂无昵称), createdTime=Tue Jun 25 00:12:00 CST 2019, time=2019-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578836, encodeId=ac4115e8836b5, content=<a href='/topic/show?id=9b395292257' target=_blank style='color:#2F92EE;'>#恶性疟原虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52922, encryptionId=9b395292257, topicName=恶性疟原虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b5f16444736, createdName=ms6832696159214430, createdTime=Tue Jun 25 00:12:00 CST 2019, time=2019-06-25, status=1, ipAttribution=)]
    2020-03-19 lsndxfj
  3. [GetPortalCommentsPageByObjectIdResponse(id=1830124, encodeId=fb3b183012438, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Dec 25 02:12:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997611, encodeId=74e0199e6111f, content=<a href='/topic/show?id=e06810222253' target=_blank style='color:#2F92EE;'>#高分辨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102222, encryptionId=e06810222253, topicName=高分辨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Mar 19 14:12:00 CST 2020, time=2020-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387876, encodeId=5dab138e87609, content=<a href='/topic/show?id=25ffe04313d' target=_blank style='color:#2F92EE;'>#疟原虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70431, encryptionId=25ffe04313d, topicName=疟原虫)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e622500011, createdName=12498484m46(暂无昵称), createdTime=Tue Jun 25 00:12:00 CST 2019, time=2019-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578836, encodeId=ac4115e8836b5, content=<a href='/topic/show?id=9b395292257' target=_blank style='color:#2F92EE;'>#恶性疟原虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52922, encryptionId=9b395292257, topicName=恶性疟原虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b5f16444736, createdName=ms6832696159214430, createdTime=Tue Jun 25 00:12:00 CST 2019, time=2019-06-25, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1830124, encodeId=fb3b183012438, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Dec 25 02:12:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997611, encodeId=74e0199e6111f, content=<a href='/topic/show?id=e06810222253' target=_blank style='color:#2F92EE;'>#高分辨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102222, encryptionId=e06810222253, topicName=高分辨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Mar 19 14:12:00 CST 2020, time=2020-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387876, encodeId=5dab138e87609, content=<a href='/topic/show?id=25ffe04313d' target=_blank style='color:#2F92EE;'>#疟原虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70431, encryptionId=25ffe04313d, topicName=疟原虫)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e622500011, createdName=12498484m46(暂无昵称), createdTime=Tue Jun 25 00:12:00 CST 2019, time=2019-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578836, encodeId=ac4115e8836b5, content=<a href='/topic/show?id=9b395292257' target=_blank style='color:#2F92EE;'>#恶性疟原虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52922, encryptionId=9b395292257, topicName=恶性疟原虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b5f16444736, createdName=ms6832696159214430, createdTime=Tue Jun 25 00:12:00 CST 2019, time=2019-06-25, status=1, ipAttribution=)]

相关资讯

STM:肯尼亚发现疟疾疫苗新靶点

目前,研究人员发现了有助于对抗疟疾的新疫苗靶点。在这项研究中,研究人员采用一种新的大规模的方法,用一组感染儿童免疫系统产生的抗体,检测来自恶性疟原虫(Plasmodium falciparum)的一个蛋白库。相关研究结果发表在2014年7月30日的《科学转化医学》(Science Translational Medicine)杂志。 该试验检测儿童免疫系统响

NEJM:RTS,S/AS01疟疾疫苗的多态性和有效性

RTS,S/AS01疟疾疫苗是一种重组抗原,即由RTS和S两种蛋白质组合而成,RTS是环子孢子蛋白,一种恶性疟NF54株的表面抗原成分,S是乙肝病毒表面抗原,这两种蛋白自发地进入细胞内形成聚合微粒结构,从而发挥疫苗的功能。该疫苗只是恶性疟原虫疫苗,针对恶性疟原虫的环子孢子蛋白,不过对儿童和婴幼儿临床和严重疟疾有部分保护作用。研究者进行了一项研究,探究该疫苗对环子孢子蛋白位点上确定基因型的寄生虫的有

NEJM:恶性疟原虫K13-螺旋桨多态性的世界地图

近期在减少全球疟疾负担的过程中遇到了恶性疟原虫对青蒿素耐药性的难题。而决定这种耐药性的主要因素是部分恶性疟原虫基因编码kelch(K13)-螺旋桨域的突变,这一发现为监测全球这种耐药性提供了机会。 研究共纳入了59个疟疾流行的国家的14037个样本以分析K13-螺旋桨序列多态性。84.5%的样本取自用于接受抗疟药物耐药性全国监测点治疗的患者。通过邻近位点的单体型分析研究人员评估了突变的出现和传播。

Nat Chemistry:N-肉豆蔻酰基转移酶——抗疟药物作用新靶点

日前,科学家们发现一种方法,能够阻止疟疾寄生虫的繁殖,向疟疾新疗法迈出了重要的一步。这项研究成果,发表在12月22日的Nature Chemistry杂志上。研究人员发现,阻断最常见的疟原虫中的一种NMT酶(N-Myristoyltransferase,N-肉豆蔻酰基转移酶)的活性,能够防止小鼠表现疟疾症状,并延长它们的寿命。研究团队正在致力于设计能够更好地靶定NMT的分子,并有望在

Nature:关于恶性疟原虫免疫逃逸机制的新发现

  中科院上海巴斯德研究所江陆斌研究组科研人员新近首次发现了恶性疟原虫在人体内实现免疫逃逸的表观遗传分子机制,其研究论文近日在线发表在国际学术刊物《自然》杂志上。专家认为,该研究结果对人们更好理解真核生物基因调控以及疟疾疫苗的研发具有科学意义。 恶性疟原虫的基因组编码是一个由60个基因组成的var基因家族。该基因家族的蛋白翻译产物PfEMP1在恶性疟原虫感染红细胞后可被运输至红细胞膜