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Clinica Chimica Acta：疑似家族性高胆固醇血症患者的冠状动脉疾病和风险相关LPA变异？

2020-08-09 MedSci原创 MedSci原创

家族性高胆固醇血症患者高胆固醇血症患者
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研究表明LPA中rs3798220和rs10455872单核苷酸多态性(SNPs)与血浆脂蛋白(a) [Lp(a)]浓度升高和冠状动脉疾病(CAD)相关。

研究表明LPA中rs3798220和rs10455872单核苷酸多态性(SNPs)与血浆脂蛋白(a) [Lp(a)]浓度升高和冠状动脉疾病(CAD)相关。研究人员调查了763例疑似家族性高胆固醇血症(FH)患者rs3798220和rs10455872与流行的CAD之间的关系。利用SEQUENOM平台检测LPA中rs3798220和rs10455872的SNP。

两组LPA SNPs均与冠心病显著相关，但校正其他危险因素后仅与rs3798220相关(优势比[OR] 2.05;95%置信区间[CI] 1.02-4.12;p = 0.045)，在校正Lp(a)浓度后均无变化。两个SNP均与Lp(a)增加呈正相关且独立相关(rs3798220: OR 1.27;95%可信区间0.96 - -1.57;p < 0.001。rs10455872: 1.41;95%可信区间1.24 - -1.58;p < 0.001)。Lp(a)的血浆浓度与流行的CAD独立相关(或1.28;(95% CI 1.08-1.52, p = 0.005)，校正LPA SNPs和其他心血管危险因素后，虽然rs3798220和rs10455872 snp均与疑似FH患者中Lp(a)浓度和普遍的CAD相关，但这并非独立于Lp(a)浓度。

研究结果表明，量化Lp(a)比评估这些Lp(a)相关SNP更有可能用于增强CAD风险预测。

原始出处：

Michael M. Page，Katrina L. Ellis，Coronary artery disease and the risk-associated LPA variants, rs3798220 and rs10455872, in patients with suspected familial hypercholesterolaemia

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    2021-03-31 windight

    #CTA#

    0

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    2020-08-11 howi

    #冠状动脉疾病#

    0

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    2020-08-11 12498dabm77暂无昵称

    #变异#

    0

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    2020-08-11 刘阔

    #高胆固醇血症#

    0

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    2020-08-11 ms9474365431325850

    #LPA#

    0

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    2020-08-11 wetgdt

    #家族性#

    0

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    2020-08-10 yangchou

    学习了，谢谢

    0

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