Ann Rheum Dis:修订的欧洲硬皮病试验和研究组活动指数是短期严重程度增加的更佳预测指标

2019-08-20 xiangting MedSci原创

调整后的平均EUSTAR-AI对SSc的疾病进展和严重器官受累的预测价值最佳。

欧洲硬皮病试验和研究组(EUSTAR)最近开发了一种初步修订的活动指数(AI),其在系统性硬化症(SSc)中的表现优于欧洲硬皮病研究组活动指数(EScSG-AI)。

这项研究旨在评估与EScSG-AI和已知的不良预后因素相比,EUSTAR-AI对短期疾病严重程度增加的预测价值。

首先提取来自EUSTAR数据库的SSc患者,这些患者的病程从初次非雷诺征/症状开始≤5年并在2003年至2014年间进行了基线访视。为了获得疾病活动性随时间的变化,计算EUSTAR-AI和EScSG-AI调整的平均值。主要结局是疾病进展,定义为2年随访时的Medsger严重程度评分Δ≥1并在不同项目。进行Logistic 回归分析以确定预测因子。

共纳入549名患者。在多因素分析中,EUSTAR-AI调整后的平均值是2年内严重程度增加和肺、心脏、皮肤和外周血管疾病的唯一预测指标。

调整后的平均EUSTAR-AI对SSc的疾病进展和严重器官受累的预测价值最佳。

原始出处:

Serena Fasano. Revised European Scleroderma Trials and Research Group Activity Index is the best predictor of short-term severity accrual. Ann Rheum Dis. 17 August 2019.

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