Gut:炎症性肠病与较高的痴呆症风险有关

2020-06-25 MedSci原创 MedSci原创

这项基于人群的队列研究表明IBD与痴呆症之间存在显著关联。在IBD患者中,老年痴呆症的诊断年龄较早,且随着IBD的发展,疾病风险似乎也有所增加。这些结果强调了未来的研究需要阐明IBD和痴呆之间的关系。

越来越多的证据支持疾病状态下肠道与中枢神经系统之间存在相互交流,称为“肠-脑轴”。最近的研究表明IBD与帕金森氏病的发展之间存在联系。尚未有研究探讨IBD在痴呆症中的作用。

近日,消化病领域权威杂志Gut上发表了一篇研究文章,研究人员使用台湾国民健康保险研究数据库,对1742名≥45岁的IBD患者与17420名对照者进行了比较分析,以评估IBD诊断后痴呆症的风险。根据性别、获得的医疗保健、收入和痴呆症相关合并症与对照者进行匹配。对所有个体进行痴呆随访长达16年。次要分析包括性别、溃疡性结肠炎(UC)和克罗恩病(CD)与痴呆症风险之间的关系。

IBD患者痴呆的总体发生率显著升高(5.5% vs 1.4%)。IBD患者痴呆症诊断的平均年龄为76.24岁,而对照组为83.45岁。IBD患者发展为痴呆的HR为2.54(95%CI为1.91至3.37)。在所有类型的痴呆症中,患阿尔茨海默氏症的风险增加最明显。UC和CD与痴呆风险之间的性别差异一致。

这项基于人群的队列研究表明IBD与痴呆症之间存在显著关联。在IBD患者中,老年痴呆症的诊断年龄较早,而且随着IBD的发展,疾病风险似乎也有所增加。这些结果强调了未来的研究需要阐明IBD和痴呆之间的关系。

原始出处:

Bing Zhang.et al.Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study.Gut.2020.http://dx.doi.org/10.1136/gutjnl-2020-320789

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    2020-12-24 Boyinsh
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    2020-06-25 junJUN

    老年人痴呆何药可用??

    0

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    2020-06-25 ms9000001904643643

    真详细

    0

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