JAHA:阿托伐他汀可通过改善肾功能降低心血管风险

2019-04-26 不详 MedSci原创

肾功能会随着年龄变大而降低,这种降低对肾和心血管疾病是一个很好的预测因子。他汀类药物可以降低心血管疾病风险,这可能会其对肾功能的益处有关。本研究的目的旨在评估阿托伐他汀对肾功能的影响,及其对心血管结局的影响。本研究分析了6个大型阿托伐他汀临床试验的数据,并对30621名患者的血清肌酐倒数的斜率代表肾功能的改变([Mg/DL]-1/y)进行了分析。患者根据治疗方法分成了三类:安慰剂组(n = 10

肾功能会随着年龄变大而降低,这种降低对肾和血管疾病是一个很好的预测因子。他汀类药物可以降低血管疾病风险,这可能会其对肾功能的益处有关。本研究的目的旨在评估阿托伐他汀对肾功能的影响,及其对心血管结局的影响。

本研究分析了6个大型阿托伐他汀临床试验的数据,并对30621名患者的血清肌酐倒数的斜率代表肾功能的改变([Mg/DL]-1/y)进行了分析。患者根据治疗方法分成了三类:安慰剂组(n = 10 057),阿托伐他汀10毫克每日(N = 12 763)和80 mg每日(N = 7801)。结果分析显示,这三组患者的血清肌酐倒数的斜率分别是 0.009 (0.0008), 0.011 (0.0006)和0.014 (0.0006) (mg/dL)-1/y,10mg和80mg组患者的斜率存在统计学差异(P=0.0009)。另外,采用Cox比例风险模型,以斜率作为预测因子,发现肾功能与心血管结局之间存在显着的负相关(p<0.0001)。

研究结果显示,在存在心血管风险的患者中,阿托伐他汀通过剂量依赖方式可以改善患者肾功能,且与心血管风险的降低呈相关性。

原始出处:

本文系梅斯医学(MedSci)原创编译整理,转载需授权

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1850712, encodeId=4df41850e127d, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Thu Oct 17 07:28:00 CST 2019, time=2019-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082501, encodeId=81272082501f4, content=<a href='/topic/show?id=56658981223' target=_blank style='color:#2F92EE;'>#血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89812, encryptionId=56658981223, topicName=血管风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Sun Feb 09 21:28:00 CST 2020, time=2020-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818660, encodeId=9105181866079, content=<a href='/topic/show?id=841398124b3' target=_blank style='color:#2F92EE;'>#降低心血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98124, encryptionId=841398124b3, topicName=降低心血管风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cdcd18, createdName=bshuang, createdTime=Sun Sep 08 17:28:00 CST 2019, time=2019-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936547, encodeId=7589193654e0c, content=<a href='/topic/show?id=d5b382495e2' target=_blank style='color:#2F92EE;'>#肾功能降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82495, encryptionId=d5b382495e2, topicName=肾功能降低)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLx96cCLjNYsHar1XErTVibOydfEC9iaYgrXp3SicXwntSAEDeQAlM2vLqTfm6oPORxaib3UIgyHQJJ7A/132, createdBy=36f02500138, createdName=ms6980045490879608, createdTime=Sun Dec 22 20:28:00 CST 2019, time=2019-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268127, encodeId=86c0126812e15, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Apr 28 06:28:00 CST 2019, time=2019-04-28, status=1, ipAttribution=)]
    2019-10-17 yese
  2. [GetPortalCommentsPageByObjectIdResponse(id=1850712, encodeId=4df41850e127d, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Thu Oct 17 07:28:00 CST 2019, time=2019-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082501, encodeId=81272082501f4, content=<a href='/topic/show?id=56658981223' target=_blank style='color:#2F92EE;'>#血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89812, encryptionId=56658981223, topicName=血管风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Sun Feb 09 21:28:00 CST 2020, time=2020-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818660, encodeId=9105181866079, content=<a href='/topic/show?id=841398124b3' target=_blank style='color:#2F92EE;'>#降低心血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98124, encryptionId=841398124b3, topicName=降低心血管风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cdcd18, createdName=bshuang, createdTime=Sun Sep 08 17:28:00 CST 2019, time=2019-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936547, encodeId=7589193654e0c, content=<a href='/topic/show?id=d5b382495e2' target=_blank style='color:#2F92EE;'>#肾功能降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82495, encryptionId=d5b382495e2, topicName=肾功能降低)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLx96cCLjNYsHar1XErTVibOydfEC9iaYgrXp3SicXwntSAEDeQAlM2vLqTfm6oPORxaib3UIgyHQJJ7A/132, createdBy=36f02500138, createdName=ms6980045490879608, createdTime=Sun Dec 22 20:28:00 CST 2019, time=2019-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268127, encodeId=86c0126812e15, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Apr 28 06:28:00 CST 2019, time=2019-04-28, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1850712, encodeId=4df41850e127d, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Thu Oct 17 07:28:00 CST 2019, time=2019-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082501, encodeId=81272082501f4, content=<a href='/topic/show?id=56658981223' target=_blank style='color:#2F92EE;'>#血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89812, encryptionId=56658981223, topicName=血管风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Sun Feb 09 21:28:00 CST 2020, time=2020-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818660, encodeId=9105181866079, content=<a href='/topic/show?id=841398124b3' target=_blank style='color:#2F92EE;'>#降低心血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98124, encryptionId=841398124b3, topicName=降低心血管风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cdcd18, createdName=bshuang, createdTime=Sun Sep 08 17:28:00 CST 2019, time=2019-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936547, encodeId=7589193654e0c, content=<a href='/topic/show?id=d5b382495e2' target=_blank style='color:#2F92EE;'>#肾功能降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82495, encryptionId=d5b382495e2, topicName=肾功能降低)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLx96cCLjNYsHar1XErTVibOydfEC9iaYgrXp3SicXwntSAEDeQAlM2vLqTfm6oPORxaib3UIgyHQJJ7A/132, createdBy=36f02500138, createdName=ms6980045490879608, createdTime=Sun Dec 22 20:28:00 CST 2019, time=2019-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268127, encodeId=86c0126812e15, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Apr 28 06:28:00 CST 2019, time=2019-04-28, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1850712, encodeId=4df41850e127d, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Thu Oct 17 07:28:00 CST 2019, time=2019-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082501, encodeId=81272082501f4, content=<a href='/topic/show?id=56658981223' target=_blank style='color:#2F92EE;'>#血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89812, encryptionId=56658981223, topicName=血管风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Sun Feb 09 21:28:00 CST 2020, time=2020-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818660, encodeId=9105181866079, content=<a href='/topic/show?id=841398124b3' target=_blank style='color:#2F92EE;'>#降低心血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98124, encryptionId=841398124b3, topicName=降低心血管风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cdcd18, createdName=bshuang, createdTime=Sun Sep 08 17:28:00 CST 2019, time=2019-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936547, encodeId=7589193654e0c, content=<a href='/topic/show?id=d5b382495e2' target=_blank style='color:#2F92EE;'>#肾功能降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82495, encryptionId=d5b382495e2, topicName=肾功能降低)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLx96cCLjNYsHar1XErTVibOydfEC9iaYgrXp3SicXwntSAEDeQAlM2vLqTfm6oPORxaib3UIgyHQJJ7A/132, createdBy=36f02500138, createdName=ms6980045490879608, createdTime=Sun Dec 22 20:28:00 CST 2019, time=2019-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268127, encodeId=86c0126812e15, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Apr 28 06:28:00 CST 2019, time=2019-04-28, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1850712, encodeId=4df41850e127d, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Thu Oct 17 07:28:00 CST 2019, time=2019-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082501, encodeId=81272082501f4, content=<a href='/topic/show?id=56658981223' target=_blank style='color:#2F92EE;'>#血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89812, encryptionId=56658981223, topicName=血管风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Sun Feb 09 21:28:00 CST 2020, time=2020-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818660, encodeId=9105181866079, content=<a href='/topic/show?id=841398124b3' target=_blank style='color:#2F92EE;'>#降低心血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98124, encryptionId=841398124b3, topicName=降低心血管风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cdcd18, createdName=bshuang, createdTime=Sun Sep 08 17:28:00 CST 2019, time=2019-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936547, encodeId=7589193654e0c, content=<a href='/topic/show?id=d5b382495e2' target=_blank style='color:#2F92EE;'>#肾功能降低#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82495, encryptionId=d5b382495e2, topicName=肾功能降低)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLx96cCLjNYsHar1XErTVibOydfEC9iaYgrXp3SicXwntSAEDeQAlM2vLqTfm6oPORxaib3UIgyHQJJ7A/132, createdBy=36f02500138, createdName=ms6980045490879608, createdTime=Sun Dec 22 20:28:00 CST 2019, time=2019-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268127, encodeId=86c0126812e15, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Apr 28 06:28:00 CST 2019, time=2019-04-28, status=1, ipAttribution=)]
    2019-04-28 仁心济世

相关资讯

JACC:PCI可降低老年STEMI合并心源性休克患者死亡率

年龄大于等于75岁的老年人在ST段抬高型心肌梗死(STEMI)合并心源性休克后死亡率会增加。本研究的目的旨在评估经皮冠脉介入治疗(PCI)在老年STEMI合并心源性休克患者中的应用及其对住院死亡率的影响。本研究纳入了1999-2013年美国317728名STEMI合并休克的患者,其中年龄≥75岁的占35%,女性占53%。老年STEMI合并休克患者的诊断例数逐年减少,但是老年患者的PCI率逐年增加,

JACC:冠脉搭桥手术的当代预后优于以往

随着经皮冠脉介入治疗(PCI)技术的成熟,其预后也越来越好,但是外科治疗的预后变化情况尚不清楚。本研究的目的旨在比较评估目前接受冠脉搭桥手术(CABG)患者的预后和之前手术患者的预后。本研究对SYNTAX临床试验(2005-2007年)中的CABG患者和EXCEL临床试验(2010-2014)中的CABG患者进行了倾向性匹配分析,所有患者均有左主干冠脉疾病,伴有或不伴有多支冠脉病变。主要终点事件是

JACC:心源性休克并发急性心肌梗死患者的多器官衰竭研究

目前,关于心源性休克并发急性心肌梗死(AMI-CS)的急性非心脏多器官衰竭的资料尚缺乏。本研究纳入了2000-2014年444253名AMI-CS入院患者,其中非心脏单器官和多器官衰竭的发生率分别是32.4%和31.9%。多器官衰竭在非ST段抬高型AMI-CS患者、非白种人和基线并发症更多的患者中更常见,单器官和多器官衰竭发生率逐年增加。冠脉造影和血运重建在多器官衰竭患者中更少见。单器官衰竭(OR

盘点:JACC四月第三期研究一览

1.慢性主动脉瓣反流患者的预后研究DOI: 10.1016/

JACC:经导管三尖瓣重建治疗中重度三尖瓣反流安全有效

严重的三尖瓣反流(TR)与高的死亡率相关,且治疗手段有限。本研究的目的旨在评估经导管三尖瓣重建系统在30例中重度TR患者中的6个月安全性和有效性。本研究纳入了TRI-REPAIR临床研究中的30例中重度、有临床症状的且不适外科手术治疗的TR患者,并对患者术前及术后6个月的临床、功能和超声心动图资料进行分析。患者的平均年龄为75岁,女性占73%,23%患者有缺血性心脏病,在基线水平,有83%的患者的