Bone:PHPT患者体内维生素D、PTH和钙水平存在季节变化

2016-07-24 Mechront 译 MedSci原创

背景和目的:对于原发性甲状旁腺功能亢进(PHPT),25羟维生素D、PTH和钙水平的季节变化情况情况还没有得到很好的研究。就此我们进行了一项研究,探究这些参数的季节变化,并评估这些季节变化是否会影响临床决策。方法:研究者基于以色列南部2000-2012年的电子病历进行了回顾性研究。纳入≥18岁的PHPT患者(PTH>正常上限(ULN),血清钙>10.5mg %)。肾衰竭或使用噻嗪类利尿药的患

背景和目的:对于原发性甲状旁腺功能亢进(PHPT),25羟维生素D、PTH和钙水平的季节变化情况情况还没有得到很好的研究。就此我们进行了一项研究,探究这些参数的季节变化,并评估这些季节变化是否会影响临床决策。

方法:研究者基于以色列南部2000-2012年的电子病历进行了回顾性研究。纳入≥18岁的PHPT患者(PTH>正常上限(ULN),血清钙>10.5mg %)。肾衰竭或使用噻嗪类利尿药的患者排除在外。所有患者的血清钙、甲状旁腺素和25羟维生素D等数据根据季节进行分层。

结果:792例PHPT (72.2%为女性)患者,进行了2659次PTH测试、1395次25羟基维生素D和7426次血清钙测试。56%的25羟基维生素D水平<50nmol/L。三个参数均有季节性:夏季平均25羟维生素D比冬季高出13%(P<0.001);平均PTH值则相反,夏季比冬季下降约8.4%(P<0.001);血清钙水平在秋天更高,比春天和夏天高出0.2mg/dL(P<0.001);血清钙水平在11.5mg/dL以上的OR值在秋天最高(OR=1.275, P=0.018)。

结论:研究者观察到了PHPT患者的25羟维生素D、PTH和钙水平的季节变化;这些季节性的变化,可能涉及病理值,可能一定程度上会影响PHPT的诊断和治疗。

原始出处:

Nevo-Shor A,et al.Seasonal changes in serum calcium, PTH and vitamin D levels in patients with primary hyperparathyroidism.Bone. 2016 Aug;89:59-63. doi: 10.1016/j.bone.2016.05.012. Epub 2016 May 31.

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    2016-11-21 lujian
  2. 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    2017-04-17 jeanqiuqiu
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time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595562, encodeId=3471159556237, content=<a href='/topic/show?id=8d3b1420ea5' target=_blank style='color:#2F92EE;'>#PHPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14207, encryptionId=8d3b1420ea5, topicName=PHPT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99fc18261354, createdName=雕雕, createdTime=Tue Jul 26 12:14:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2017-01-20 apoenzyme
  4. 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time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595562, encodeId=3471159556237, content=<a href='/topic/show?id=8d3b1420ea5' target=_blank style='color:#2F92EE;'>#PHPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14207, encryptionId=8d3b1420ea5, topicName=PHPT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99fc18261354, createdName=雕雕, createdTime=Tue Jul 26 12:14:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-09-20 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

  5. 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time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595562, encodeId=3471159556237, content=<a href='/topic/show?id=8d3b1420ea5' target=_blank style='color:#2F92EE;'>#PHPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14207, encryptionId=8d3b1420ea5, topicName=PHPT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99fc18261354, createdName=雕雕, createdTime=Tue Jul 26 12:14:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-09-17 1e10c84am36(暂无匿称)

    不错哦,会学到很多,喜欢梅斯医学文章

    0

  6. 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time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595562, encodeId=3471159556237, content=<a href='/topic/show?id=8d3b1420ea5' target=_blank style='color:#2F92EE;'>#PHPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14207, encryptionId=8d3b1420ea5, topicName=PHPT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99fc18261354, createdName=雕雕, createdTime=Tue Jul 26 12:14:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-09-13 舒心和人

    很有道理,顺四时,调心智,机体也是在不同的季节呈现出不同的状态

    0

  7. 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objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 18:22:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=113284, encodeId=e56211328441, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Wed Sep 07 17:19:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107225, encodeId=f0f910e2255b, content=好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 30 10:34:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468659, encodeId=93701468659e3, content=<a href='/topic/show?id=a19b4540688' target=_blank style='color:#2F92EE;'>#季节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45406, encryptionId=a19b4540688, topicName=季节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cf986929326, createdName=30397606, createdTime=Tue Jul 26 12:14:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595562, encodeId=3471159556237, content=<a href='/topic/show?id=8d3b1420ea5' target=_blank style='color:#2F92EE;'>#PHPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14207, encryptionId=8d3b1420ea5, topicName=PHPT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99fc18261354, createdName=雕雕, createdTime=Tue Jul 26 12:14:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-09-07 李东泽

    很好,不错,以后会多学习

    0

  8. 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encodeId=f0f910e2255b, content=好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 30 10:34:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468659, encodeId=93701468659e3, content=<a href='/topic/show?id=a19b4540688' target=_blank style='color:#2F92EE;'>#季节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45406, encryptionId=a19b4540688, topicName=季节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cf986929326, createdName=30397606, createdTime=Tue Jul 26 12:14:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595562, encodeId=3471159556237, content=<a href='/topic/show?id=8d3b1420ea5' target=_blank style='color:#2F92EE;'>#PHPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14207, encryptionId=8d3b1420ea5, topicName=PHPT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99fc18261354, createdName=雕雕, createdTime=Tue Jul 26 12:14:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-08-30 ylzr123

    好文,值得学习,赞!

    0

  9. 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time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595562, encodeId=3471159556237, content=<a href='/topic/show?id=8d3b1420ea5' target=_blank style='color:#2F92EE;'>#PHPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14207, encryptionId=8d3b1420ea5, topicName=PHPT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99fc18261354, createdName=雕雕, createdTime=Tue Jul 26 12:14:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-07-26 30397606
  10. 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encodeId=f0f910e2255b, content=好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 30 10:34:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468659, encodeId=93701468659e3, content=<a href='/topic/show?id=a19b4540688' target=_blank style='color:#2F92EE;'>#季节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45406, encryptionId=a19b4540688, topicName=季节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cf986929326, createdName=30397606, createdTime=Tue Jul 26 12:14:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595562, encodeId=3471159556237, content=<a href='/topic/show?id=8d3b1420ea5' target=_blank style='color:#2F92EE;'>#PHPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14207, encryptionId=8d3b1420ea5, topicName=PHPT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99fc18261354, createdName=雕雕, createdTime=Tue Jul 26 12:14:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-07-26 雕雕