Diabetes:1型糖尿病患者心血管疾病的风险

2016-05-24 MedSci MedSci原创

有关2型糖尿病的心血管危险因素已经为人们所熟知,而1型糖尿病却并非如此。然而1型糖尿病与年龄匹配的非糖尿病患者相比具有更高的罹患心血管疾病的风险。研究人员对糖尿病控制和并发症试验(DCCT)中的1型糖尿病患者进行了长期随访(平均27年)和危险因素的评估。ox比例风险回归模型用于评估传统的及新发现的危险因素,包括HbA1c、动脉粥样硬化性心血管事件(MACE)(包括致死性或非致死性心肌梗死或中风)以

有关2型糖尿病的心血管危险因素已经为人们所熟知,而1型糖尿病却并非如此。然而1型糖尿病与年龄匹配的非糖尿病患者相比具有更高的罹患心血管疾病的风险。

研究人员对糖尿病控制和并发症试验(DCCT)中的1型糖尿病患者进行了长期随访(平均27年)和危险因素的评估。cox比例风险回归模型用于评估传统的及新发现的危险因素,包括HbA1c、动脉粥样硬化性心血管事件(MACE)(包括致死性或非致死性心肌梗死或中风)以及any-CVD(MACE加心绞痛、无症状性心梗、血管重建和充血性心力衰竭)。

结果显示,年龄及平均HbA1c无论与any-CVD或是MACE均呈现显著相关性。HbA1c每增加1个百分比,any-CVD和MACE的风险分别增加31%和42%。心血管疾病(CVD)和MACE与其他7个传统因素相关,如血压、血脂、未使用ACEI等,但与性别无关。any-CVD和MACE的年龄-HbA1c曲线下面积分别为0.70和0.77;纳入所有危险因素后的最终模型,any-CVD和MACE的曲线下面积分别为0.75和0.82。

虽然很多传统的心血管疾病危险因素都适用于1型糖尿病,但高血糖症也是一个仅次于年龄的危险因素。

原始出处:

Nathan DM,Bebu I,Braffett BH,et al.Risk Factors for Cardiovascular Disease in Type 1 Diabetes.Diabetes. 2016;65(5):1370-1379.

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  5. 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topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Thu May 26 07:37:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497995, encodeId=46d5149e99574, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu May 26 07:37:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87197, encodeId=367d8e197b1, content=一型,二型,有什么区别?, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/3B3BF0051F5289FA5E81ADFC54B1C14B/100, createdBy=27091728826, createdName=QQ6562edab, createdTime=Wed May 25 20:04:00 CST 2016, time=2016-05-25, status=1, ipAttribution=)]
    2016-06-02 沉心多思

    好文章,得多学习了!

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/3B3BF0051F5289FA5E81ADFC54B1C14B/100, createdBy=27091728826, createdName=QQ6562edab, createdTime=Wed May 25 20:04:00 CST 2016, time=2016-05-25, status=1, ipAttribution=)]
    2016-05-28 清河

    1型2型有区别,1型:患病年龄小,多是因为β细胞受损胰岛素分泌不足,治疗上需要用胰岛素2型患病年龄偏大,中老年人居多,多是因为胰岛素进行性分泌不足伴胰岛素抵抗

    0

  7. 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    2016-05-26 tiantian569

    一型,二型,有什么区别?

    0

  8. 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  9. 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  10. 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    2016-05-25 QQ6562edab

    一型,二型,有什么区别?

    0

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Diabetes Care:人工胰腺治疗1型糖尿病儿童

意大利帕多瓦大学信息工程部门的Claudio Cobelli博士和同事对30名5-9岁1型糖尿病儿童进行了一项随机交叉研究,患者进行3天人工胰腺和3天家长管理式传感器增强胰岛素泵治疗。两组均使用稀释Novolog(速效门冬胰岛素,Novo Nordisk),两种治疗方式间存在24小时的洗脱期。夜间低血糖发生率从传感器增强胰岛素泵治疗时的2.2%,下降到人工胰腺治疗时的0%(P = .002)。传感

Diabetes Care:降脂治疗可减少1型糖尿病患者CVD的发生及死亡风险

据发表于 Diabetes Care的一项新的研究显示,无心血管疾病史的1型糖尿病患者,降脂治疗或可降低其心血管疾病和心血管死亡的发生风险。