Cell Reports :“成熟”分子帮助青春期的大脑发育

2017-11-01 MedSci MedSci原创

10月31日发表在《细胞报告》(Cell Reports)杂志上的一项研究表明,在抚养青少年的过程中,父母有一个盟友-- laminin alpha 5,这种分子对青少年大脑的成熟至关重要。十多年来,耶鲁团队一直在寻找一个基本问题的答案: 大脑是如何通过细胞间突触连接的疯狂增长而发育成熟的?"直到成年早期,细胞之间的突触是野生型的,更具塑性; 它们会萎缩、生长甚至破坏姐妹神经突触。"资深作者Ant

10月31日发表在《细胞报告》(Cell Reports)杂志上的一项研究表明,在抚养青少年的过程中,父母有一个盟友-- laminin alpha 5,这种分子对青少年大脑的成熟至关重要。十多年来,耶鲁团队一直在寻找一个基本问题的答案: 大脑是如何通过细胞间突触连接的疯狂增长而发育成熟的?"直到成年早期,细胞之间的突触是野生型的,更具塑性; 它们会萎缩、生长甚至破坏姐妹神经突触。"资深作者Anthony Koleske说,他是分子生物物理与生物化学和神经科学教授。"在成熟的大脑中,突触变得更加克制,它们体积更小,行为更加规范。"这项新研究指出,青少年思维形成的关键信号是一种叫做层粘连蛋白(laminin)家族的片段,在其他生物功能中如神经肌肉功能起着至关重要的作用。研究人员发现,缺乏laminin alpha 5基因的老鼠在突触成熟过程中有缺陷,在成年早期就会出现突触减少。突触研究人员忽略了层粘连蛋白,因为它们相对较大的尺寸使得它们不可能在脑中突触的紧密空间内起作用。新的研究结果表明,蛋白质片段与青春期脑突触受体结合,引发了成熟过程,Koleske说。Koleske实验室的研究生和研

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    2018-05-07 维他命
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1950533, encodeId=f4f21950533d7, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Sat Jan 27 21:47:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870252, encodeId=bc3118e025200, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Aug 02 14:47:00 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960515, encodeId=22af196051527, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon May 07 04:47:00 CST 2018, time=2018-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275521, encodeId=b5a812e55212f, content=<a href='/topic/show?id=5d0299032b9' target=_blank style='color:#2F92EE;'>#青春期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99032, encryptionId=5d0299032b9, topicName=青春期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Fri Nov 03 11:47:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347233, encodeId=1091134e23390, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Fri Nov 03 11:47:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399534, encodeId=036f1399534dd, content=<a href='/topic/show?id=abae4388359' target=_blank style='color:#2F92EE;'>#大脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43883, encryptionId=abae4388359, topicName=大脑发育)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/ED2CC9E7989F19A8FE1EC8C4B58CDA69/100, createdBy=cdee2217473, createdName=gj0732, createdTime=Fri Nov 03 11:47:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258133, encodeId=29f0258133c0, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Nov 02 21:12:47 CST 2017, time=2017-11-02, status=1, ipAttribution=)]
    2017-11-03 neurowu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1950533, encodeId=f4f21950533d7, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Sat Jan 27 21:47:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870252, encodeId=bc3118e025200, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Aug 02 14:47:00 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960515, encodeId=22af196051527, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon May 07 04:47:00 CST 2018, time=2018-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275521, encodeId=b5a812e55212f, content=<a href='/topic/show?id=5d0299032b9' target=_blank style='color:#2F92EE;'>#青春期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99032, encryptionId=5d0299032b9, topicName=青春期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Fri Nov 03 11:47:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347233, encodeId=1091134e23390, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Fri Nov 03 11:47:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399534, encodeId=036f1399534dd, content=<a href='/topic/show?id=abae4388359' target=_blank style='color:#2F92EE;'>#大脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43883, encryptionId=abae4388359, topicName=大脑发育)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/ED2CC9E7989F19A8FE1EC8C4B58CDA69/100, createdBy=cdee2217473, createdName=gj0732, createdTime=Fri Nov 03 11:47:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258133, encodeId=29f0258133c0, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Nov 02 21:12:47 CST 2017, time=2017-11-02, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1950533, encodeId=f4f21950533d7, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Sat Jan 27 21:47:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870252, encodeId=bc3118e025200, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Aug 02 14:47:00 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960515, encodeId=22af196051527, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon May 07 04:47:00 CST 2018, time=2018-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275521, encodeId=b5a812e55212f, content=<a href='/topic/show?id=5d0299032b9' target=_blank style='color:#2F92EE;'>#青春期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99032, encryptionId=5d0299032b9, topicName=青春期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Fri Nov 03 11:47:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347233, encodeId=1091134e23390, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Fri Nov 03 11:47:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399534, encodeId=036f1399534dd, content=<a href='/topic/show?id=abae4388359' target=_blank style='color:#2F92EE;'>#大脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43883, encryptionId=abae4388359, topicName=大脑发育)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/ED2CC9E7989F19A8FE1EC8C4B58CDA69/100, createdBy=cdee2217473, createdName=gj0732, createdTime=Fri Nov 03 11:47:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258133, encodeId=29f0258133c0, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Nov 02 21:12:47 CST 2017, time=2017-11-02, status=1, ipAttribution=)]
    2017-11-02 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0