J Gastroenterology: 肽353抗体可作为小儿克罗恩氏病的诊断标志物

2020-05-01 MedSci原创 MedSci原创

据报道,各种血清学标志物,例如抗糖蛋白2抗体和抗酿酒酵母抗体,在克罗恩氏病中可用于诊断。目前,有人提出,针对克罗恩氏病肽353(一种新提出的血清学标志物)的抗体在日本成年人中比抗酵母菌更有用。

背景: 据报道,各种血清学标志物,例如抗糖蛋白2抗体和抗酿酒酵母抗体,在克罗恩氏病中可用于诊断。目前,有人提出,针对克罗恩氏病肽353(一种新提出的血清学标志物)的抗体在日本成年人中比抗酵母菌更有用。因此,本项研究旨在在儿童患者中进行相关验证。

方法: 研究人员在日本的12个儿科中心收集了17岁以下的包括克罗恩病,溃疡性结肠炎,其他肠道疾病或健康状况良好的人群。通过酶联免疫吸附试验分析了3种血清标志物。

结果: 入选受试者为367名,其中包括120名克罗恩氏病,148名溃疡性结肠炎,56名其他肠道疾病和43名健康受试者。在克罗恩氏病中,抗克罗恩氏病肽353,抗糖蛋白2和抗酵母菌浓度(中位数为2.25、3.0和8.9 U/mL)显着高于溃疡性结肠炎(分别为1.1、1.9和3.4;P <0.001),其他肠道疾病(1.1、1.85和2.95;P <0.001)和健康对照组(1.1、1.7和2.8;P <0.001)。在95%的特异性下,抗克罗恩氏病肽(45.0%)的敏感性显着高于抗糖蛋白2(30.8%; P <0.05)或抗酵母菌的敏感性(26.7%;P <0.01)。

结论: 与其他2种标记相比,抗克罗恩氏病多肽353被证明对日本儿童克罗恩氏病的诊断更有用。 

原始出处:

Tatsuki Mizuochi. Et al. Antibodies to Crohn’s disease peptide 353 as a diagnostic marker for pediatric Crohn’s disease: a prospective multicenter study in Japan. J Gastroenterology.2020.

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2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382466, encodeId=53563824666a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kMagl3IvXZ0BWO3HJQ3hVO1urtfCZXQYQ6k0ibyOCThBA2cW0LqCM6K17qjpQBtver6QacI9A3jK3lNWJ4M14icQ/132, createdBy=e6eb5276926, createdName=szdxlk, createdTime=Sun May 03 23:04:59 CST 2020, time=2020-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505003, encodeId=be84150500343, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, 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    2020-10-15 许安
  5. 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  6. 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  7. 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    2020-05-03 szdxlk

    学习了

    0

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