Am J Clin Nutr:女性膳食脂肪酸摄入对生殖激素和排卵的影响

2016-02-05 Seven L 译 MedSci原创

新的证据表明,某些膳食脂肪酸和提高生育率之间具有潜在联系,因为特定的脂肪酸会影响前列腺素的合成和分泌。研究者对259名月经规律的女性进行了一项研究,评估总的和具体的膳食脂肪摄入量和激素浓度之间的关系,以及散发性排卵障碍的风险。参与者每个周期检测8次内源性生殖激素,共两个周期;每个周期都会评估24小时膳食摄入量。使用混合线性模型和广义线性模型被评估膳食脂肪酸与生殖激素水平和排卵情况间的联系。所有模型

新的证据表明,某些膳食脂肪酸的摄入和提高生育率之间具有潜在联系,因为特定的脂肪酸会影响前列腺素的合成和分泌。

研究者对259名月经规律的女性进行了一项研究,评估总的和具体的膳食脂肪摄入量和激素浓度之间的关系,以及散发性排卵障碍的风险。

参与者每个周期检测8次内源性生殖激素,共两个周期;每个周期都会评估24小时膳食摄入量。使用混合线性模型和广义线性模型被评估膳食脂肪酸与生殖激素水平和排卵情况间的联系。所有模型都对总能量摄入、年龄、身体质量指数和种族等混杂因素进行了校正。

研究数据显示,总脂肪所占能量百分比最低组有——总睾酮和游离睾酮浓度增加最多(总睾酮增加4%;95% CI:0.7%,7.3%;游离睾酮:4.1%;95% CI:0.5%,7.7%)。多不饱和脂肪酸(PUFA)所占能量比例最高组与总睾酮和游离睾酮增加有关(总睾酮增加3.7%;95% CI:0.6%,6.8%;游离睾酮:4%;95% CI:0.5%,7.5%)。多不饱和脂肪酸二十二碳五烯酸(22:5n–3)与睾酮浓度没有统计学意义(P-trend = 0.86),但会增加孕激素、降低排卵障碍的风险(最高组与最低组:RR:0.42;95% CI:0.18,0.95)。脂肪摄入量与其他生殖激素浓度无关。

研究结果表明,总脂肪的摄入,尤其是多不饱和脂肪酸的摄入量,与健康女性睾酮浓度小幅度的增加有关,此外增加二十二碳五烯酸可降低排卵障碍风险。

原始出处:

Sunni L Mumford, Jorge E Chavarr,et al.Dietary fat intake and reproductive hormone concentrations and ovulation in regularly menstruating women.Am J Clin Nutr.First published February 3, 2016, doi: 10.3945/​ajcn.115.119321


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    2016-07-06 zhouqu_8
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    2016-02-07 1de48a27m96(暂无匿称)

    非常好

    0

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    2016-02-07 1de48a27m96(暂无匿称)

    了解

    0

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    2016-02-06 dhzzm

    很好,值得学习

    0

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    2016-02-06 zhaojie88
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