BMJ:新冠肺炎患者呼吸道、粪便、血清和尿液病毒载量研究

2020-04-22 MedSci原创 MedSci原创

SARS-CoV-2在粪便中的持续时间明显长于呼吸道和血清,突出了在预防和控制疫情中需要加强患者粪便管理

近日研究人员评估了浙江省2019年严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)流行前四个月,患者疾病不同阶段的病毒载量。
 
本次研究为回顾性队列研究,在中国浙江省covid-19患者定点医院开展。总计包含96例实验室确诊的SARS-CoV-2感染患者,其中轻症22例,重症74例。数据收集时间为2020年1月19日至2020年3月20日。研究的主要终点为在呼吸道、粪便、血清和尿液样本中病毒核糖核酸(RNA)载量。
 
入院后收集3497份呼吸道、粪便、血清和尿液样本,并对SARS-CoV-2RNA病毒载量进行评估。所有患者均经痰液和唾液样本检测确诊感染。55例(59%)患者粪便和39例(41%)患者血清中检测到RNA。1名病人的尿液样本为SARS-CoV-2阳性。粪便中病毒持续时间中位数(22天,四分位数范围17-31天)明显长于呼吸道(18天,13-29天;P=0.02)和血清(16天,11-21天;P<0.001)。重症患者(21天,14-30天)呼吸道病毒中位持续时间明显长于轻症患者(14天,10-21天,P=0.04)。轻症患者病毒载量在发病后第2周达到高峰,重度组病毒载量在发病后第3周持续高位。60岁以上患者和男性患者的病毒持续时间较长。
 
研究发现,SARS-CoV-2在粪便中的持续时间明显长于呼吸道和血清,突出了在预防和控制疫情中需要加强患者粪便管理。
 
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    2020-05-08 gaoxiaoe
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    2020-04-24 zhmscau
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    2020-04-24 Homburg
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    2020-04-22 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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