J Rheumatol:原发性干燥综合征与非霍奇金淋巴瘤的双向关系

2020-01-16 xiangting MedSci原创

这项基于人群的研究是首个报告pSS与NHL之间存在双向关系的研究。该研究结果提示应对临床治疗中有其他疾病早期迹象的pSS或NHL患者保持警惕。

一些自身免疫性疾病与非霍奇金淋巴瘤NHL)之间可能存在双向关系。这是一项台湾基于人群的研究,旨在探讨原发性干燥综合征(pSS)与非霍奇金淋巴瘤NHL)之间是否存在双向关系。

研究人员使用台湾健康保险研究数据库,确定了1998年至201215636名既往无癌症的新发pSS患者和25074名既往无pSS的新发NHL患者,这是两个非重叠队列,并随访至2013年。将pSS患者中NHL的标准化发病率(SIR)和NHL患者中pSSSIR与一般人群进行比较。

15636pSS患者中,741名出现癌症,其中51名为NHLpSS患者特定癌症风险的最高SIRNHLSIR 4.695CI 3.4-6.0)。在25074NHL患者中,有49名出现了pSSSIR也有所提高(SIR 3.295CI 2.4-4.2)。疾病诊断后一年内的风险最高。

这项基于人群的研究是首个报告pSSNHL之间存在双向关系的研究。该研究结果提示应对临床治疗中有其他疾病早期迹象的pSSNHL患者保持警惕。双向关系的潜在机制值得进一步研究。

原始出处:

Li-Hui Wang. Bidirectional Relationship Between Primary Sjögren’s Syndrome and Non- Hodgkin’s Lymphoma: A Nationwide Population-based Study. J Rheumatol. 15 January 2020.

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