Hum Reprod:吸烟对多囊卵巢综合征妇女妊娠并发症风险的影响

2021-07-04 MedSci原创 MedSci原创

妊娠期吸烟可进一步增加PCOS患者的GDM风险

多囊卵巢综合征(PCOS)是女性最常见的内分泌疾病之一,在一般人群中的患病率为6-13%。PCOS的临床特征包括排卵和月经不规律、高雄激素血症、超声多囊卵巢、代谢功能障碍和胰岛素抵抗。因此,PCOS患者的2型糖尿病(DM)的发病率也随之增加。而且,吸烟的PCOS患者患妊娠期糖尿病(GDM)的风险也增加。但是,吸烟与PCOS孕妇的妊娠并发症之间的相关性尚未完全明确。

这是一项回顾性的以人群为基础的研究,利用了来自HCUP-NIS从2004年-2014年期间的数据。将有无吸烟的PCOS孕妇进行对比,还对比了有无PCOS的吸烟孕妇。

共纳入了443590位妊娠期吸烟的孕妇、14882位患有PCOS的孕妇、631位患有PCOS同时妊娠期吸烟的孕妇。

有无吸烟的PCOS患者的妊娠和分娩结局

分析结果显示,患有PCOS的孕妇吸烟与否的早产(校正风险比[aOR] 1.2)、胎盘早剥(aOR 1.1)、妊娠诱导性高血压(aOR 1.0)、阴道侧切率(aOR 1.5)和剖腹产率(aOR 1.0)均无明显差异。在PCOS孕妇中观察到吸烟和GDM之间存在显著关联(aOR 1.5)。

综上所述,该研究结果表明,妊娠期吸烟可进一步增加PCOS患者的GDM风险,但对早产、胎盘早剥、剖腹产率等妊娠并发症无明显影响

原始出处:

Feferkorn I,Badeghiesh A,Mills G et al. The effects of smoking on pregnancy risks in women with polycystic ovary syndrome: a population-based study.[J] .Hum Reprod, 2021, https://doi.org/10.1093/humrep/deab145

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    2021-09-10 丁鹏鹏
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    2021-07-06 sunylz

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