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Oncotarget：小分子SI113与有丝分裂纺锤体毒素能够协同阻止多形性胶质母细胞瘤的生长

2017-12-21 MedSci MedSci原创

多形性胶质母细胞瘤紫杉醇SI113
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多形性胶质母细胞瘤（GBM）是最致命的一种脑部肿瘤。 即使最先进的GBM治疗方法也不能确保控制以高突变频率为特征的疾病的复发。为了寻找新的治疗方法，意大利的研究人员评价了癌症药物库的化合物对ADF GBM细胞的作用，以探究这些小分子化合物是否能够提高肿瘤细胞对有丝分裂纺锤体毒素的敏感性。

多形性胶质母细胞瘤（GBM）是最致命的一种脑部肿瘤。 即使最先进的GBM治疗方法也不能确保控制以高突变频率为特征的疾病的复发。为了寻找新的治疗方法，意大利的研究人员评价了癌症药物库的化合物对ADF GBM细胞的作用，以探究这些小分子化合物是否能够提高肿瘤细胞对有丝分裂纺锤体毒素的敏感性。

研究人员先前的研究结果显示，有丝分裂纺锤体毒素紫杉醇对肿瘤细胞生长的高效抑制要依靠RANBP1蛋白的表达（RANBP1受丝氨酸/苏氨酸激酶SGK1的调控）。而近期，研究人员发现了小分子化合物SI113对SGK1的抑制作用，因此小分子SI113与纺锤体毒素之间的关系便成了他们研究的重点，结果显示，SI113与纺锤体毒素能够协同性地对GBM細胞起到杀伤作用，大幅度降低了GBM細胞的生存能力，体内实验也表明它们能够抑制肿瘤组织的生长。

因为SI113显示出了全身低毒性，而且能够强化放射性疗法对GBM细胞的影响，我们完全有理由认为SI113可以作为候选化合物用以治疗多形性胶质母细胞瘤。

原始出处：

Abbruzzese, Claudia, et al. "The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme." Oncotarget 2017 8.67. doi.org/10.18632/oncotarget.22500

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    2018-08-01 宋威

    #小分子#

    0

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    2018-04-25 mei531

    #多形性胶质母细胞瘤#

    0

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    2018-05-03 30397604

    #胶质母细胞#

    0

  4. 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createdName=mei531, createdTime=Wed Apr 25 20:13:00 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2052878, encodeId=7fa720528e830, content=<a href='/topic/show?id=ae848406335' target=_blank style='color:#2F92EE;'>#胶质母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84063, encryptionId=ae848406335, topicName=胶质母细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Thu May 03 00:13:00 CST 2018, time=2018-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029050, encodeId=0048202905018, content=<a href='/topic/show?id=27134324425' target=_blank style='color:#2F92EE;'>#多形性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43244, encryptionId=27134324425, topicName=多形性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed Jun 06 05:13:00 CST 2018, time=2018-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1772254, encodeId=44a11e72254b0, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Mon Sep 10 13:13:00 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795500, encodeId=dd381e9550069, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Sun Oct 21 14:13:00 CST 2018, time=2018-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274333, encodeId=80732e433382, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Mon Jan 01 02:33:53 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274106, encodeId=1ec22e410640, content=作者, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Sun Dec 31 09:29:08 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273656, encodeId=b49d2e36568e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Sat Dec 30 00:00:16 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273362, encodeId=d2fa2e33621c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Fri Dec 29 00:09:30 CST 2017, time=2017-12-29, status=1, ipAttribution=)]
    2018-06-06 12498568m50暂无昵称

    #多形性#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1914658, encodeId=e22819146586a, content=<a href='/topic/show?id=84d7469559b' target=_blank style='color:#2F92EE;'>#小分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46955, encryptionId=84d7469559b, topicName=小分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Wed Aug 01 08:13:00 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986770, encodeId=1a2d1986e7094, content=<a href='/topic/show?id=fc7b4324614' target=_blank style='color:#2F92EE;'>#多形性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43246, encryptionId=fc7b4324614, topicName=多形性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, createdName=mei531, createdTime=Wed Apr 25 20:13:00 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2052878, encodeId=7fa720528e830, content=<a href='/topic/show?id=ae848406335' target=_blank style='color:#2F92EE;'>#胶质母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84063, encryptionId=ae848406335, topicName=胶质母细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Thu May 03 00:13:00 CST 2018, time=2018-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029050, encodeId=0048202905018, content=<a href='/topic/show?id=27134324425' target=_blank style='color:#2F92EE;'>#多形性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43244, encryptionId=27134324425, topicName=多形性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed Jun 06 05:13:00 CST 2018, time=2018-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1772254, encodeId=44a11e72254b0, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Mon Sep 10 13:13:00 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795500, encodeId=dd381e9550069, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Sun Oct 21 14:13:00 CST 2018, time=2018-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274333, encodeId=80732e433382, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Mon Jan 01 02:33:53 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274106, encodeId=1ec22e410640, content=作者, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Sun Dec 31 09:29:08 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273656, encodeId=b49d2e36568e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Sat Dec 30 00:00:16 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273362, encodeId=d2fa2e33621c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Fri Dec 29 00:09:30 CST 2017, time=2017-12-29, status=1, ipAttribution=)]
    2018-09-10 huperzia

    #母细胞瘤#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1914658, encodeId=e22819146586a, content=<a href='/topic/show?id=84d7469559b' target=_blank style='color:#2F92EE;'>#小分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46955, encryptionId=84d7469559b, topicName=小分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Wed Aug 01 08:13:00 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986770, encodeId=1a2d1986e7094, content=<a href='/topic/show?id=fc7b4324614' target=_blank style='color:#2F92EE;'>#多形性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43246, encryptionId=fc7b4324614, topicName=多形性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, createdName=mei531, createdTime=Wed Apr 25 20:13:00 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2052878, encodeId=7fa720528e830, content=<a href='/topic/show?id=ae848406335' target=_blank style='color:#2F92EE;'>#胶质母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84063, encryptionId=ae848406335, topicName=胶质母细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Thu May 03 00:13:00 CST 2018, time=2018-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029050, encodeId=0048202905018, content=<a href='/topic/show?id=27134324425' target=_blank style='color:#2F92EE;'>#多形性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43244, encryptionId=27134324425, topicName=多形性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed Jun 06 05:13:00 CST 2018, time=2018-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1772254, encodeId=44a11e72254b0, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Mon Sep 10 13:13:00 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795500, encodeId=dd381e9550069, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Sun Oct 21 14:13:00 CST 2018, time=2018-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274333, encodeId=80732e433382, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Mon Jan 01 02:33:53 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274106, encodeId=1ec22e410640, content=作者, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Sun Dec 31 09:29:08 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273656, encodeId=b49d2e36568e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Sat Dec 30 00:00:16 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273362, encodeId=d2fa2e33621c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Fri Dec 29 00:09:30 CST 2017, time=2017-12-29, status=1, ipAttribution=)]
    2018-10-21 闆锋旦

    #target#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1914658, encodeId=e22819146586a, content=<a href='/topic/show?id=84d7469559b' target=_blank style='color:#2F92EE;'>#小分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46955, encryptionId=84d7469559b, topicName=小分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Wed Aug 01 08:13:00 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986770, encodeId=1a2d1986e7094, content=<a href='/topic/show?id=fc7b4324614' target=_blank style='color:#2F92EE;'>#多形性胶质母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43246, encryptionId=fc7b4324614, topicName=多形性胶质母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, 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encryptionId=27134324425, topicName=多形性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed Jun 06 05:13:00 CST 2018, time=2018-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1772254, encodeId=44a11e72254b0, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Mon Sep 10 13:13:00 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795500, encodeId=dd381e9550069, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, 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level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Sun Dec 31 09:29:08 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273656, encodeId=b49d2e36568e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Sat Dec 30 00:00:16 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273362, encodeId=d2fa2e33621c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Fri Dec 29 00:09:30 CST 2017, time=2017-12-29, status=1, ipAttribution=)]
    2018-01-01 麻醉僧

    学习

    0

  8. 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level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Sun Dec 31 09:29:08 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273656, encodeId=b49d2e36568e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Sat Dec 30 00:00:16 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273362, encodeId=d2fa2e33621c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Fri Dec 29 00:09:30 CST 2017, time=2017-12-29, status=1, ipAttribution=)]
    2017-12-31 麻醉僧

    作者

    0

  9. 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level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/e6ae4d6996235d5b5d2f416737192359.jpg, createdBy=ba621669454, createdName=麻醉僧, createdTime=Fri Dec 29 00:09:30 CST 2017, time=2017-12-29, status=1, ipAttribution=)]
    2017-12-30 麻醉僧

    学习

    0

  10. 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    2017-12-29 麻醉僧

    学习

    0

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