SCI REP:转氨酶水平反映呼吸道合胞病毒(RSV)毛细支气管炎患儿的疾病严重程度!

2018-01-30 xing.T MedSci原创

由此可见,RSV毛细支气管炎在AST水平早期升高的儿童中更为严重,因此,其可以在疾病早期用作疾病严重程度的预测指标。

由呼吸道合胞病毒(RSV)引起的细支气管炎是婴儿期最常见的住院原因。细支气管炎患儿血清转氨酶有时会升高。近日,Scientific reports杂志上发表了一篇研究文章,研究人员旨在检测转氨酶升高与毛细支气管炎患儿疾病严重程度增加相关的假设。

该研究是对社区获得性RSV毛细支气管炎的机械通气儿童进行了一项前瞻性观察性队列研究。每天测量了参与者丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST)水平。将转氨酶正常的儿童与升高水平的儿童进行比较。

连续11个冬季,556名RSV毛细支气管炎患儿接受了机械通气 ,其中226人患有合并症,因此被排除在外;其余330名中有313名未满2岁; 305名参与者进行了早期转氨酶测量。57/305(19%)的参与者转氨酶(AST和/或ALT)水平升高。这是第一次表明入院时AST水平升高(而不是ALT水平升高)的患者,通气时间和入院时间延长、儿科死亡指数和C反应蛋白升高。此外,转氨酶升高是短暂的,通常在入院后七天内回归正常。

由此可见,RSV毛细支气管炎在AST水平早期升高的儿童中更为严重,因此,其可以在疾病早期用作疾病严重程度的预测指标。

原始出处:


Kentigern Thorburn,et al. Transaminase levels reflect disease severity in children ventilated for respiratory syncytial virus (RSV) bronchiolitis.Scientific reports.2018. https://www.nature.com/articles/s41598-018-20292-6

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    2018-02-03 一个字-牛

    学习了谢谢分享

    0

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beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63695, encryptionId=dc4f63695a8, topicName=毛细支气管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=be0f14453443, createdName=rebeccajiejie, createdTime=Thu Feb 01 00:59:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283608, encodeId=e3b42836086f, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jan 30 21:37:28 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283500, encodeId=9b6528350020, content=诊疗进展值得借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jan 30 11:57:36 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
  5. 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createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Dec 01 21:59:00 CST 2018, time=2018-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284710, encodeId=bff2284e10eb, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sat Feb 03 09:21:03 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804894, encodeId=c2451804894a7, content=<a href='/topic/show?id=a2ece7762cb' target=_blank style='color:#2F92EE;'>#细支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77762, encryptionId=a2ece7762cb, topicName=细支气管)], attachment=null, 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topicId=null, topicList=[TopicDto(id=93386, encryptionId=252d93386f8, topicName=转氨酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Thu Feb 01 00:59:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507511, encodeId=95c5150e51136, content=<a href='/topic/show?id=d33f15e143f' target=_blank style='color:#2F92EE;'>#RSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15714, encryptionId=d33f15e143f, topicName=RSV)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f939898798, createdName=feather81, createdTime=Thu Feb 01 00:59:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553873, encodeId=943115538e378, content=<a href='/topic/show?id=dc4f63695a8' target=_blank style='color:#2F92EE;'>#毛细支气管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63695, encryptionId=dc4f63695a8, topicName=毛细支气管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=be0f14453443, createdName=rebeccajiejie, createdTime=Thu Feb 01 00:59:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283608, encodeId=e3b42836086f, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jan 30 21:37:28 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283500, encodeId=9b6528350020, content=诊疗进展值得借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jan 30 11:57:36 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-02-01 zhmscau
  6. [GetPortalCommentsPageByObjectIdResponse(id=1717606, encodeId=18ac1e1760675, content=<a href='/topic/show?id=dba6e776367' target=_blank style='color:#2F92EE;'>#细支气管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77763, encryptionId=dba6e776367, topicName=细支气管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=285132431847, createdName=kcb080, createdTime=Sun Dec 23 17:59:00 CST 2018, time=2018-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892135, encodeId=28591892135d7, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicId=null, topicList=[TopicDto(id=93386, encryptionId=252d93386f8, topicName=转氨酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Thu Feb 01 00:59:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507511, encodeId=95c5150e51136, content=<a href='/topic/show?id=d33f15e143f' target=_blank style='color:#2F92EE;'>#RSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15714, encryptionId=d33f15e143f, topicName=RSV)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f939898798, createdName=feather81, createdTime=Thu Feb 01 00:59:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553873, encodeId=943115538e378, content=<a href='/topic/show?id=dc4f63695a8' target=_blank style='color:#2F92EE;'>#毛细支气管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63695, encryptionId=dc4f63695a8, topicName=毛细支气管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=be0f14453443, createdName=rebeccajiejie, createdTime=Thu Feb 01 00:59:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283608, encodeId=e3b42836086f, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jan 30 21:37:28 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283500, encodeId=9b6528350020, content=诊疗进展值得借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jan 30 11:57:36 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-02-01 仁医06
  7. [GetPortalCommentsPageByObjectIdResponse(id=1717606, encodeId=18ac1e1760675, content=<a href='/topic/show?id=dba6e776367' target=_blank style='color:#2F92EE;'>#细支气管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77763, encryptionId=dba6e776367, topicName=细支气管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=285132431847, createdName=kcb080, createdTime=Sun Dec 23 17:59:00 CST 2018, time=2018-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892135, encodeId=28591892135d7, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jan 30 11:57:36 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-02-01 feather81
  8. 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  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63695, encryptionId=dc4f63695a8, topicName=毛细支气管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=be0f14453443, createdName=rebeccajiejie, createdTime=Thu Feb 01 00:59:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283608, encodeId=e3b42836086f, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Jan 30 21:37:28 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283500, encodeId=9b6528350020, content=诊疗进展值得借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jan 30 11:57:36 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-01-30 thlabcde

    好资料学习了!

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jan 30 11:57:36 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-01-30 虈亣靌

    诊疗进展值得借鉴

    0

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