Int J Cardiol:他汀类药物治疗对冠心病患者未成熟血小板计数的影响

2018-08-11 xing.T MedSci原创

由此可见,该研究表明在CAD的患者中,使用他汀类药物不会影响未成熟血小板计数或主要的血小板参数。

他汀类药物是冠状动脉疾病(CAD)患者的关键疗法,具有降脂和多效、抗血栓和抗炎的益处。不成熟血小板计数(IPC)作为较年轻且可能更具反应性的血小板的分数,因此可潜在地影响主要血管缺血事件的风险。近日,血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,该研究的目的是评估他汀类药物治疗对冠心病患者IPC的影响。

研究人员纳入了在单个中心进行冠状动脉造影的患者。入院时接受他汀类药物治疗或未接受他汀类药物治疗的患者IPC水平是通过常规血细胞计数(A Sysmex XE-2100)来测量得到,作为未成熟血小板分数(IPF)和血小板计数的产物。

该研究纳入了642名患者,61.2%的患者在入院时接受他汀类药物治疗。接受长期他汀类药物治疗的患者更多是男性,代谢特征较差,但总胆固醇和低密度脂蛋白胆固醇较低,主要心血管危险因素的患病率较高。IPC的平均水平在他汀类药物治疗组和未接受他汀类药物治疗组患者之间无差异(7.9±4.7 vs. 7.7±5,p=0.60),IPC的三分位数分布也没有差异(p=0.36)。 事实上,在多变量回归分析中,他汀类药物的使用并不与IPC高于第3个三分位数的患者独立相关(调整后的OR [95%CI] =1.19 [0.80-1.79],p=0.39)。此外,在入院时引入他汀类药物治疗的190名患者中,与长期治疗或未治疗的患者相比,IPC和主要血小板参数的水平在32天的中位随访时没有差异。

由此可见,该研究表明在CAD的患者中,使用他汀类药物不会影响未成熟血小板计数或主要的血小板参数。

原始出处:

MonicaVerdoia,et al. Impact of statin therapy on the immature platelet count in patients with coronary artery disease: A single centre cohort study.International Journal of Cardiology.2018. https://doi.org/10.1016/j.ijcard.2018.08.039

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    2018-08-23 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  5. 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    2018-08-12 131****1460

    学习了受益匪浅

    0

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    2018-08-11 惠映实验室

    学习了,谢谢分享。

    0

  9. 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    2018-08-11 phoebeyan520

    学习了,谢谢分享

    0

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    2018-08-11 happsf

    学习

    0

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由此可见,在妊娠前期接触他汀类药物与胎儿室间隔缺损有关。

Int J Cardiol:他汀类药物/依折麦布联合对慢性肾脏病患者冠状动脉粥样硬化斑块的影响!

由此可见,与非CKD相比,CKD患者采用阿托伐他汀/依折麦布强化降脂治疗与阿托伐他汀单药治疗相比可获得更强的冠状动脉斑块消退效应。

JAHA:他汀类药物使用与颈动脉血管重建术后心血管事件的关系

由此可见,连续接受他汀类药物治疗与明显的颈动脉疾病患者长期不良心血管事件风险降低25%相关。除了其他支持性证据外,在接受颈动脉血运重建术的患者中应考虑采用他汀类药物治疗,并且需要努力增加这类治疗不足人群的他汀类药物使用比例。