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CLIN CANCER RES：p27和Cyclin D1表达与HER2+早期乳腺癌Trastuzumab治疗获益的关系

2018-07-04 MedSci MedSci原创

乳腺癌Trastuzumabp27CyclinD
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CLIN CANCER RES近期发表了一篇文章，研究与细胞周期调节或细胞增殖有关的分子在HER2+早期乳腺癌中的预后和预测价值。

CLIN CANCER RES近期发表了一篇文章，研究与细胞周期调节或细胞增殖有关的分子在HER2+早期乳腺癌中的预后和预测价值。

作者分析了HERA临床试验的862例肿瘤标本支撑的组织芯片，其中Trastuzumab组561例，观察组301例，使用免疫组化检测组织芯片中TOP2A，Ki67，cyclin D1和p27表达情况。主要的研究终点为无病生存。使用多因素Cox模型分析分子标志与治疗之间的关系。研究结果表明，p27与治疗之间存在显着相关性。在p27低表达亚组中Trastuzumab疗效明显。在P27高表达亚组中未观察到Trastuzumab治疗效果，表明这部分患者接受Trastuzumab几乎没有临床获益。研究还观察到p27对无病生存的预后效果。TOP2A，Ki67，cyclin D1，作为分类变量时无预测作用，而cyclin D1作为连续变量时可以预测Trastuzumab获益。

文章最后认为，在TransHERA试验中，p27低表达的HER2+早期乳腺癌患者接受Trastuzumab治疗有临床获益，而高p27表达的患者没有。

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    2019-01-12 ms24272190615788285182

    #AST#

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    2019-04-13 snf701207

    #mAb#

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    2019-01-31 bsmagic9140

    #TRA#

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    2018-07-06 jyzxjiangqin

    早期乳腺癌的治疗.

    0

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    2018-07-04 大爰

    学习了谢谢分享!!

    0

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    2018-07-04 kafei

    学习学习谢谢

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