Clinical Nutrition: 白蛋白-球蛋白评分和骨骼肌指数的组合可以有效预测肝内胆管癌手术患者的预后

2021-05-09 MedSci原创 MedSci原创

肌肉减少症的特征在于骨骼肌质量的丧失,并且肌肉减少症与术后不良结局相关。

        肌肉减少症的特征在于骨骼肌质量的丧失,并且肌肉减少症与术后不良结局相关。这项研究旨在评估术前白蛋白-球蛋白评分(AGS),骨骼肌指数(SMI)以及它们的组合在肝内胆管癌(ICC)手术切除患者中的预后价值。

 

       研究人员回顾性分析了来自两个医疗中心的总共613例新诊断的ICC患者(模型构建队列中有460例,验证队列中153例)。普通计算机断层扫描图像(CT)用于测量SMI。然后研究人员分析了AGS,SMI和(白蛋白-球蛋白-骨骼肌指数)CAS等级对ICC患者临床病理特征和长期预后的影响。

 

        研究结果显示男性的SMI明显高于女性。AGS降低,SMI升高的患者与总生存期(OS)和无复发生存期(RFS)相关。按CAS等级划分,1级的68名患者(14.8%)与体重指数(BMI)升高和术后预后最佳相关,而3级的194名患者(42.1%)与最差的OS和RFS相关。CAS评分在预测ICC患者的OS和RFS方面显示出更好的准确性(曲线下面积[AUC]为0.732和0.768)。

 

       本研究通过大样本人群研究证实基于术前AGS和SMI组合的新指标与经手术治疗的ICC患者的术后长期预后密切相关。术前评估CAS等级可能有助于ICC患者的风险分类和临床治疗决策。

 

 

原始出处:

Hui Li. Et al. Combination of albumin-globulin score and skeletal muscle index predicts long-term outcomes of intrahepatic cholangiocarcinoma patients after curative resection. Clinical Nutrition.2021.

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    2021-06-14 xzw113
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    2021-08-30 ms4000001628606281

    😕

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    2021-05-11 珙桐
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    2021-05-11 zll0628
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