Eur Heart J:睡眠觉醒负担与长期全因和心血管疾病死亡率之间的关联

2021-04-20 MedSci原创 MedSci原创

夜间AB与女性的长期CV和全因死亡率相关,而在男性中则相关性较低。

近日,血管领域权威杂志Eur Heart J上发表了一篇研究文章,该研究旨在量化大型队列研究中觉醒负担(AB),并确定其与男性和女性的长期心血管(CV)以及总死亡率之间的关系。

研究人员对骨质疏松性骨折研究(MrOS)中2782名男性患者、骨质疏松性骨折研究(SOF)的424名女性和睡眠心脏健康研究(SHHS)的2221名男性和2574名女性的夜间多导睡眠图结果测量了AB。

在11.2±2.1年随访期间,665名男性患者死亡,包括236例CV死亡。在SOF研究中的随访6.4±1.6年期间,有105名妇女死亡,其中47例CV死亡。在SHHS研究中的10.7±3.1年的随访期间,有987人死亡,其中344人死于CV。

在女性中,针对常见混杂因素进行的多变量Cox比例风险分析表明,AB与全因死亡率[SOF:风险比(HR)1.58(1.01-2.42),P=0.038;SHHS妇女:HR为1.21(1.06-1.42),P=0.012]和CV死亡率[SOF:HR为2.17(1.04-4.50),P=0.037; SHHS妇女:HR为1.60(1.12–2.28),P=0.009]相关。在男性中,AB与全因死亡率[MrOS:HR为1.11(0.94–1.32),P=0.261;SHHS男性:HR为1.31(1.06-1.62),P=0.011]和CV死亡率[MrOS:HR为1.35(1.02-1.79),P=0.034; SHHS男性:HR为1.24(0.86–1.79),P=0.271]之间的关联尚不明确。

由此可见,夜间AB与女性的长期CV和全因死亡率相关,而在男性中则相关性较低

原始出处:

Sobhan Salari Shahrbabaki.et al.Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women.European Heart Journal.2021.https://doi.org/10.1093/eurheartj/ehab151

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    2021-11-06 guoyibin
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    2021-04-22 zhaojie88
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    2021-04-22 slcumt
  5. [GetPortalCommentsPageByObjectIdResponse(id=1645372, encodeId=5a7016453e23c, content=<a href='/topic/show?id=adfe9090e2b' target=_blank style='color:#2F92EE;'>#觉醒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90907, encryptionId=adfe9090e2b, topicName=觉醒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=36f323200284, createdName=guoyibin, createdTime=Sat Nov 06 21:56:28 CST 2021, time=2021-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357692, encodeId=e8d4135e69206, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Apr 22 12:56:28 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498867, encodeId=c946149886e00, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Apr 22 12:56:28 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563447, encodeId=c7d7156344e8a, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Apr 22 12:56:28 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958997, encodeId=279995899e5f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84653241162, createdName=12cc8218m69暂无昵称, createdTime=Wed Apr 21 10:07:31 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958972, encodeId=21c39589e268, content=学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210125/9e5998de75824d5f8a8e76ad7ca79433/206fffa392c54ae5a60152c166e2f362.jpg, createdBy=ab0d5455599, createdName=二爽, createdTime=Wed Apr 21 08:29:33 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958964, encodeId=82af9589643c, content=睡眠障碍是心血管关键因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Apr 21 07:13:58 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958924, encodeId=8231958924a7, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62505123547, createdName=1463ea10m76暂无昵称, createdTime=Tue Apr 20 23:12:34 CST 2021, time=2021-04-20, status=1, ipAttribution=)]
    2021-04-21 12cc8218m69暂无昵称

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1645372, encodeId=5a7016453e23c, content=<a href='/topic/show?id=adfe9090e2b' target=_blank style='color:#2F92EE;'>#觉醒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90907, encryptionId=adfe9090e2b, topicName=觉醒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=36f323200284, createdName=guoyibin, createdTime=Sat Nov 06 21:56:28 CST 2021, time=2021-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357692, encodeId=e8d4135e69206, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Apr 22 12:56:28 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498867, encodeId=c946149886e00, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Apr 22 12:56:28 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563447, encodeId=c7d7156344e8a, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Apr 22 12:56:28 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958997, encodeId=279995899e5f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84653241162, createdName=12cc8218m69暂无昵称, createdTime=Wed Apr 21 10:07:31 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958972, encodeId=21c39589e268, content=学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210125/9e5998de75824d5f8a8e76ad7ca79433/206fffa392c54ae5a60152c166e2f362.jpg, createdBy=ab0d5455599, createdName=二爽, createdTime=Wed Apr 21 08:29:33 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958964, encodeId=82af9589643c, content=睡眠障碍是心血管关键因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Apr 21 07:13:58 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958924, encodeId=8231958924a7, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62505123547, createdName=1463ea10m76暂无昵称, createdTime=Tue Apr 20 23:12:34 CST 2021, time=2021-04-20, status=1, ipAttribution=)]
    2021-04-21 二爽

    学习了学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1645372, encodeId=5a7016453e23c, content=<a href='/topic/show?id=adfe9090e2b' target=_blank style='color:#2F92EE;'>#觉醒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90907, encryptionId=adfe9090e2b, topicName=觉醒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=36f323200284, createdName=guoyibin, createdTime=Sat Nov 06 21:56:28 CST 2021, time=2021-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357692, encodeId=e8d4135e69206, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Apr 22 12:56:28 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498867, encodeId=c946149886e00, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Apr 22 12:56:28 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563447, encodeId=c7d7156344e8a, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Apr 22 12:56:28 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958997, encodeId=279995899e5f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84653241162, createdName=12cc8218m69暂无昵称, createdTime=Wed Apr 21 10:07:31 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958972, encodeId=21c39589e268, content=学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210125/9e5998de75824d5f8a8e76ad7ca79433/206fffa392c54ae5a60152c166e2f362.jpg, createdBy=ab0d5455599, createdName=二爽, createdTime=Wed Apr 21 08:29:33 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958964, encodeId=82af9589643c, content=睡眠障碍是心血管关键因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Apr 21 07:13:58 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958924, encodeId=8231958924a7, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62505123547, createdName=1463ea10m76暂无昵称, createdTime=Tue Apr 20 23:12:34 CST 2021, time=2021-04-20, status=1, ipAttribution=)]
    2021-04-21 yangchou

    睡眠障碍是心血管关键因素。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1645372, encodeId=5a7016453e23c, content=<a href='/topic/show?id=adfe9090e2b' target=_blank style='color:#2F92EE;'>#觉醒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90907, encryptionId=adfe9090e2b, topicName=觉醒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=36f323200284, createdName=guoyibin, createdTime=Sat Nov 06 21:56:28 CST 2021, time=2021-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357692, encodeId=e8d4135e69206, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Apr 22 12:56:28 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498867, encodeId=c946149886e00, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Apr 22 12:56:28 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563447, encodeId=c7d7156344e8a, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Apr 22 12:56:28 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958997, encodeId=279995899e5f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84653241162, createdName=12cc8218m69暂无昵称, createdTime=Wed Apr 21 10:07:31 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958972, encodeId=21c39589e268, content=学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210125/9e5998de75824d5f8a8e76ad7ca79433/206fffa392c54ae5a60152c166e2f362.jpg, createdBy=ab0d5455599, createdName=二爽, createdTime=Wed Apr 21 08:29:33 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958964, encodeId=82af9589643c, content=睡眠障碍是心血管关键因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Apr 21 07:13:58 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958924, encodeId=8231958924a7, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62505123547, createdName=1463ea10m76暂无昵称, createdTime=Tue Apr 20 23:12:34 CST 2021, time=2021-04-20, status=1, ipAttribution=)]
    2021-04-20 1463ea10m76暂无昵称

    有用

    0

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