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AHA 2013：EDTA螯合剂或降伴糖尿病心梗患者的心血管事件

2013-11-27 高晓方 译 医学论坛网

EDTA螯合治疗糖尿病心梗心血管事件
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于AHA 2013科学年会公布的美国一项研究表明，在年龄大于50岁且伴有糖尿病的心肌梗死后患者中，EDTA螯合剂治疗可显著减少心血管事件。但该研究并未充分证明对所有的伴糖尿病心梗后患者常规用螯合疗法。论文11月19日在线发表于《循环》（Circulation）。 【原文下载】 此项TACT研究以年龄≥50岁且既往伴有心肌梗死的患者为受试者，共633例糖尿病患者，被随机分为

于AHA 2013科学年会公布的美国一项研究表明，在年龄大于50岁且伴有糖尿病的心肌梗死后患者中，EDTA螯合剂治疗可显著减少心血管事件。但该研究并未充分证明对所有的伴糖尿病心梗后患者常规用螯合疗法。论文11月19日在线发表于《循环》（Circulation）。 【原文下载】

此项TACT研究以年龄≥50岁且既往伴有心肌梗死的患者为受试者，共633例糖尿病患者，被随机分为EDTA螯合剂组（322例）或安慰剂组（311例）。主要终点为死亡、心梗再发、卒中、冠脉血运重建或心绞痛住院；次要终点为心血管死亡、心梗再发或卒中。

结果显示，在633例（37%）糖尿病患者中，EDTA组的5年主要终点发生率显著降低（25%对38%；危险比[HR] 0.59）。对多亚组实施Bonferroni校正之后上述结果依然具有显著性（校正P=0.002）。EDTA组的全因死昂率和次要终点发生率均显著降低，但对多亚组进行校正之后显著性消失。减少1项主要终点的需治疗数为6.5。在1075例非糖尿病患者中相关事件则无减少。

原文出处：

Escolar E, Lamas GA, Mark DB, Boineau R, Goertz C, Rosenberg Y, Nahin RL, Ouyang P, Rozema T, Magaziner A, Nahas R, Lewis EF, Lindblad L, Lee KL.The Effect of an EDTA-based Chelation Regimen on Patients With Diabetes Mellitus and Prior Myocardial Infarction in the Trial to Assess Chelation Therapy (TACT).Circ Cardiovasc Qual Outcomes. 2013 Nov 19. 【原文下载】

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    2014-05-03 zhanglin3079

    #心梗患者#

    0

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    2014-06-16 hukaixun

    #血管事件#

    0

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    2013-11-29 zhaohui6731

    #AHA#

    0

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    2013-11-29 ycmayy

    #EDTA#

    0