IBD : 镁可通过上调瞬时受体电位Melastatin 6通道来减轻实验性小鼠结肠炎

2018-10-04 MedSci MedSci原创

镁(Mg)对人体健康至关重要,其主要在肠道吸收。鉴于炎症性肠病(IBD)中镁缺乏可能在调节炎症方面起到一定作用,因此,研究人员对Mg是否会影响肠道炎症的发生和发展进行了探究。

背景及目的
镁(Mg)对人体健康至关重要,其主要在肠道吸收。鉴于炎症性肠病(IBD)中镁缺乏可能在调节炎症方面起到一定作用,因此,研究人员对Mg是否会影响肠道炎症的发生和发展进行了探究。

方法
为了研究镁和疾病活动之间的相关性,研究人员在一组IBD患者中通过原子吸收光谱法测量了血红蛋白浓度。通过监测血红蛋白,体重,粪便潜血,腹泻,结肠长度和组织学,在葡聚糖硫酸钠(DSS)诱导的结肠炎的小鼠模型中评估膳食Mg调节炎症的作用。通过实时逆转录聚合酶链反应和免疫组织化学在小鼠结肠组织中评估瞬时受体电位melastatin(TRPM)6通道的表达情况。在人结肠细胞系中评估Mg对上皮屏障形成和修复的影响。

结果
研究结果表明炎性肠病患者表现出显着的镁缺乏,血清镁水平与疾病活动呈负相关。在小鼠中,缺镁的饮食导致低镁血症并加重DSS诱导的结肠炎。由于粘膜损伤和TRPM6表达减少,结肠炎严重影响肠道Mg2+吸收,补充镁可以使粘膜完整性和通道表达得到更好地恢复。

结论
本项研究结果强调了IBD患者血红蛋白的重要性,积极补充镁可能是一种安全且具有成本较低的减少炎症和恢复正常粘膜功能的策略。

原始出处:

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    2021-02-17 Susanheee

    mark

    0

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    2019-02-06 snowpeakxu
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    2019-03-07 DEXTER3139
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    2019-02-12 lujian
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    2018-10-06 bnurmamat

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