Stroke:心房纤颤伴慢性肾脏疾病发生血栓栓塞事件的风险

2014-11-30 MedSci译 MedSci原创

慢性肾脏疾病可以增加患有瓣膜性心房纤颤病人的缺血性休克和系统性栓塞的风险。我们进行了一次Meta分析来总结所有发表的研究,以调查慢性肾脏疾病和心房纤颤发生血栓栓塞事件风险之间的联系。研究方法:我们使用MEDLINE(PubMed,1966至2014-7)和EMBASE(1980至2014-7)进行了一次无限制条件的文献检索。通过运用随机效应Meta分析来获取汇集效应估计。研究结果:18项研究包括5

慢性肾脏疾病可以增加患有瓣膜性心房纤颤病人的缺血性休克和系统性栓塞的风险。我们进行了一次Meta分析来总结所有发表的研究,以调查慢性肾脏疾病和心房纤颤发生血栓栓塞事件风险之间的联系。

研究方法:

我们使用MEDLINE(PubMed,1966至2014-7)和EMBASE(1980至2014-7)进行了一次无限制条件的文献检索。通过运用随机效应Meta分析来获取汇集效应估计。

研究结果:
18项研究包括538479个病人和41719例血栓栓塞事件被确认。汇总分析表明,对进展性血栓栓塞事件,心房纤颤病人伴估计肾小球滤过率<60ml/min,对比于估计肾小球滤过率≥60ml/min的病人来讲,呈现出显著增加的风险(相对危险度1.62[95%可信区间,1.40-1.87;P<0.001])。肾功能每下降10ml/min,血栓栓塞事件的年发生率即提高0.41%(95%可信区间,0.17%-0.65%)。就CHADS2评分而言额外的肾脏损伤会轻度提高卒中风险的层级。

总结:
肾功能的损害对于患有瓣膜性心房纤颤病人的卒中或者系统性血栓发病来讲是一个独立的预测因子。对心房纤颤病人来讲,对肾功能的保护,可以改善其卒中风险分层。

原始出处:


Zeng WT1, Sun XT1, Tang K1, Mei WY1, Liu LJ1, Xu Q1, Cheng YJ2.Risk of Thromboembolic Events in Atrial Fibrillation With Chronic Kidney Disease.Stroke. 2014 Nov 25. pii: STROKEAHA.114.006881. [Epub ahead of print]


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    2014-12-19 rosa00tong

    可能与高凝状态有关?

    0

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    2014-12-02 sodoo

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