BMJ研究新闻:早期诊断并早期治疗DCIS是有必要的

2015-12-07 MedSci MedSci原创

据发表于Lancet Oncology的一项新的研究表明,乳腺导管内癌(DCIS)的早期影像发现并接受早期治疗可防止DCIS发展为浸润性乳腺癌。

据发表于Lancet Oncology的一项新的研究表明,乳腺导管内癌(DCIS)的早期影像发现并接受早期治疗可防止DCIS发展为浸润性乳腺癌。

目前研究人员正在收集使用乳房X线照相术危害机体的数据,因为潜在的过度诊断问题已引起关于DCIS筛查和治疗的争议。其中一个关键问题是DCIS的早期检测及治疗是否可防止浸润性乳腺癌的发生。

为了探究这个问题,研究人员分析5243658名年龄在50-64岁女性,均在过去的四年里接受了乳腺癌的筛查。对于诊断为DCIS的患者随访观察36个月,收集并分析数据。

研究人员评估了检测期间DCIS的诊断频率以及随后发生的间隔浸润性乳腺癌的发生率之间的关系。


结果显示,每筛查1000名女性,便有1.60人诊断为DCIS。DCIS的筛查率越高,随后3年里浸润性乳腺癌的发生率越低。

本研究中,约90%的乳腺癌筛查单位DCIS的检测率在1.00-2.22人/1000人之间。这些单位每筛查出3名DCIS女性,则未来三年便减少一名发展为浸润性乳腺癌的患者。

该研究第一作者Stephen Duffy教授说道:“DCIS是否会发展为浸润性乳腺癌仍存在争议。该研究从筛选程序来研究,其结果表明,如果不经治疗那么将会有相当比例的DCIS发展为浸润性乳腺癌,因此应当早期检测并治疗DCIS。”

最后,Stephen Duffy教授总结道,“人们可以放心的接受DCIS筛查,乳腺癌筛查项目对患者有益。”

原始出处:

Susan Mayor. Screening for early breast cancer reduces invasive cancer, study finds. BMJ 2015; 351 doi: http://dx.doi.org/10.1136/bmj.h6576.

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    2016-01-05 gaoxiaoe
  5. [GetPortalCommentsPageByObjectIdResponse(id=1993593, encodeId=718e1993593d9, content=<a href='/topic/show?id=17124e60f1' target=_blank style='color:#2F92EE;'>#CIS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4760, encryptionId=17124e60f1, topicName=CIS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Sun May 01 12:30:00 CST 2016, time=2016-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1940863, encodeId=4a1b1940863fc, content=<a href='/topic/show?id=adc65940194' target=_blank style='color:#2F92EE;'>#早期治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59401, encryptionId=adc65940194, topicName=早期治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a19115, createdName=stfoxst, createdTime=Sat Oct 22 03:30:00 CST 2016, time=2016-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661880, encodeId=6c1f166188015, content=<a href='/topic/show?id=85485e479f' target=_blank style='color:#2F92EE;'>#DCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5747, encryptionId=85485e479f, topicName=DCI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=100e25353151, createdName=ms691033630344116, createdTime=Wed Oct 19 19:30:00 CST 2016, time=2016-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847796, encodeId=a565184e79696, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Jan 05 09:30:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49622, encodeId=4b254962278, content=好学习很值得, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Dec 27 20:37:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48809, encodeId=620b488094a, content=好文章,值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:16:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48810, encodeId=72f248810dd, content=好文章,值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:16:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=45538, encodeId=af7b45538c3, content=DCIS筛查, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Fri Dec 11 12:55:00 CST 2015, time=2015-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382629, encodeId=2444138262909, content=<a href='/topic/show?id=1f4e5946422' target=_blank style='color:#2F92EE;'>#早期诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59464, encryptionId=1f4e5946422, topicName=早期诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Dec 09 12:30:00 CST 2015, time=2015-12-09, status=1, ipAttribution=)]
    2015-12-27 忠诚向上

    好学习很值得

    0

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    2015-12-27 hixiaoluo

    好文章,值得收藏

    0

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    2015-12-27 hixiaoluo

    好文章,值得收藏

    0

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    2015-12-11 jetleo

    DCIS筛查

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1993593, encodeId=718e1993593d9, content=<a href='/topic/show?id=17124e60f1' target=_blank style='color:#2F92EE;'>#CIS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4760, encryptionId=17124e60f1, topicName=CIS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Sun May 01 12:30:00 CST 2016, time=2016-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1940863, encodeId=4a1b1940863fc, content=<a href='/topic/show?id=adc65940194' target=_blank style='color:#2F92EE;'>#早期治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59401, encryptionId=adc65940194, topicName=早期治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a19115, createdName=stfoxst, createdTime=Sat Oct 22 03:30:00 CST 2016, time=2016-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661880, encodeId=6c1f166188015, content=<a href='/topic/show?id=85485e479f' target=_blank style='color:#2F92EE;'>#DCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5747, encryptionId=85485e479f, topicName=DCI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=100e25353151, createdName=ms691033630344116, createdTime=Wed Oct 19 19:30:00 CST 2016, time=2016-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847796, encodeId=a565184e79696, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Jan 05 09:30:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49622, encodeId=4b254962278, content=好学习很值得, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Dec 27 20:37:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48809, encodeId=620b488094a, content=好文章,值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:16:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48810, encodeId=72f248810dd, content=好文章,值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:16:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=45538, encodeId=af7b45538c3, content=DCIS筛查, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Fri Dec 11 12:55:00 CST 2015, time=2015-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382629, encodeId=2444138262909, content=<a href='/topic/show?id=1f4e5946422' target=_blank style='color:#2F92EE;'>#早期诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59464, encryptionId=1f4e5946422, topicName=早期诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Wed Dec 09 12:30:00 CST 2015, time=2015-12-09, status=1, ipAttribution=)]

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JAMA Oncol:早期乳腺癌患者有必要接受手术及放射治疗吗?没必要!

据发表于JAMA Oncology的一项新的研究显示,手术和放疗并不适合女性早期乳腺癌的治疗。0期乳腺癌,即导管原位癌(DCIS),是非侵袭性乳腺癌中最常见的形式,占所有的乳腺癌病例的20%。当癌细胞局限于乳导管中而并尚未扩散到周围组织变可确诊DCIS,意味着癌细胞无法转移到乳腺外。诊断为DCIS后,部分女性患者可继续发