Clinica Chimica Acta:代谢综合征患者IL-10与冠心病严重程度的关系

2019-09-22 gladiator MedSci原创

代谢综合征是增加心脏病风险的危险因素。IL-10在MetS患者冠状动脉疾病(CAD)严重程度中的作用尚不清楚。我们研究了伴有或不伴有严重冠心病的MetS患者血浆中IL-10和其他促炎细胞因子的水平。 <span style="font-size:12.0pt;mso-bidi-font-size:14.0pt; font-family:宋体;mso-ascii-font-family:Ca

代谢综合征是增加心脏病风险的危险因素。IL-10MetS患者冠状动脉疾病(CAD)严重程度中的作用尚不清楚。我们研究了伴有或不伴有严重冠心病的MetS患者血浆中IL-10和其他促炎细胞因子的水平。

研究人员对健康和MetS个体进行横断面研究。对90例患者的IL-10和其他炎性白细胞介素进行了分析。组1N = 30),患有无严重CAD代谢综合征;组2n = 30),患有代谢综合征和严重CAD(心肌梗塞或血管重建术的历史通过手术或经皮经腔冠状血管成形术用或不用支架置入执行);组3N = 30)为健康个体。

研究显示,与第2组相比,第1IL-12p= 0.018),TNF-αp= 0.007)和IL-6的水平(p = 0.010)显著较高。与第2组和第3组相比,组2IL-10水平显著较高。仅IL-10的的水平可解释 严重CAD,并在逻辑回归模型作为保护因子(OR0.896; 95CI0.818-0.981)。

研究表明METs患者中较高的IL-10水平与较低的严重CAD发生率相关,这表明即使在促炎细胞因子水平较高的情况下,其抗炎活性也具有保护作用。

原始出处:

Ana Letícia Vargas BarcelosEduardo Aires de OliveiraAssociation of IL-10 to coronary disease severity in patients with metabolic syndrome

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1849747, encodeId=c0db1849e4740, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Tue Feb 25 07:56:00 CST 2020, time=2020-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431630, encodeId=6f8d143163020, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508247, encodeId=3578150824eda, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587646, encodeId=062d158e646dd, content=<a href='/topic/show?id=a6f6962576' target=_blank style='color:#2F92EE;'>#IL-10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9625, encryptionId=a6f6962576, topicName=IL-10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a8cd17536453, createdName=xiaoyeshuang, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=)]
    2020-02-25 windight
  2. [GetPortalCommentsPageByObjectIdResponse(id=1849747, encodeId=c0db1849e4740, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Tue Feb 25 07:56:00 CST 2020, time=2020-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431630, encodeId=6f8d143163020, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508247, encodeId=3578150824eda, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587646, encodeId=062d158e646dd, content=<a href='/topic/show?id=a6f6962576' target=_blank style='color:#2F92EE;'>#IL-10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9625, encryptionId=a6f6962576, topicName=IL-10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a8cd17536453, createdName=xiaoyeshuang, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1849747, encodeId=c0db1849e4740, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Tue Feb 25 07:56:00 CST 2020, time=2020-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431630, encodeId=6f8d143163020, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508247, encodeId=3578150824eda, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587646, encodeId=062d158e646dd, content=<a href='/topic/show?id=a6f6962576' target=_blank style='color:#2F92EE;'>#IL-10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9625, encryptionId=a6f6962576, topicName=IL-10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a8cd17536453, createdName=xiaoyeshuang, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=)]
    2019-09-24 jjjiang0202
  4. [GetPortalCommentsPageByObjectIdResponse(id=1849747, encodeId=c0db1849e4740, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Tue Feb 25 07:56:00 CST 2020, time=2020-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431630, encodeId=6f8d143163020, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508247, encodeId=3578150824eda, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587646, encodeId=062d158e646dd, content=<a href='/topic/show?id=a6f6962576' target=_blank style='color:#2F92EE;'>#IL-10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9625, encryptionId=a6f6962576, topicName=IL-10)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a8cd17536453, createdName=xiaoyeshuang, createdTime=Tue Sep 24 07:56:00 CST 2019, time=2019-09-24, status=1, ipAttribution=)]

相关资讯

ESC 2019丨糖尿病管理“机”不可失,CHAT-DM研究给你新思路

现代生活可以说手机无处不在,它被广泛用于设置警报和提醒,在医疗行业,移动医疗技术目前更是在规避传统医疗随访的实际障碍中大显身手。近期在2019年欧洲心脏病学学会年会(ESC 2019)及世界心脏病大会上,阜外医院霍西茜博士代表研究团队报告CHAT-DM研究,该研究强有力地证明了一套简单、低成本的自动化短信程序改善了2型糖尿病和冠心病患者的血糖控制。研究结果同时在线发表在Circulation: C

ESC2019:葡萄牙研究称:年纪轻轻得冠心病,别埋怨遗传,而是不健康生活方式

为什么年纪轻轻就得了冠心病?都是基因惹的祸?ESC2019上一项葡萄牙研究反诘:不运动、吸烟、血压高、糖尿病、血脂高比有易感基因推动作用大多了。

Circulation:血白细胞DNA甲基化谱可预测心肌梗死和冠心病的发病风险

DNA甲基化与冠心病(CHD)有关,但目前的证据是基于小规模的横向研究。Golareh Agha等人从多个前瞻性队列中研究血液DNA甲基化与冠心病发病的关系。本研究共纳入9个以人口为基础的队列研究,来源于美国和欧洲,全部分析系了全血白细胞DNA的甲基化,并前瞻性地明确了CHD事件,包括冠状动脉功能不全/不稳定型心绞痛、心肌梗死、冠状动脉血管重建和冠状动脉死亡。并根据年龄、性别、吸烟、受教育程度、体

Radiology:预测心血管事件:左室肥厚优于冠状动脉钙化评分

根据发表在《Radiology》杂志上的一项新研究,左心室质量升高,即左心室肥大,比冠状动脉钙化评分更能预测不良心血管事件。

冠心病患者代谢指纹图谱:棕榈酸预测冠心病发病风险强大

阜外医院窦克非、朱成刚、刘倩倩等应用超高效液相色谱—飞行时间质谱联用(UHPLC-QTOF/MS)的非靶向代谢组学方法获得了中国冠心病患者群体的代谢指纹图谱,发现了105个与冠心病相关的代谢物。

JACC:阿利罗库单抗可明显改善急性冠脉综合征患者预后

急性冠脉综合征(ACS)患者和有既往冠脉搭桥手术史(CABG)患者是心血管疾病的高危人群,本研究的目的旨在评估联合阿利罗库单抗和他汀类药物对有CABG手术史的ACS患者的疗效。本研究将18924名接受高强度他汀类药物治疗但致动脉粥样硬化脂蛋白水平仍较高的ACS患者,随机分成皮下注射阿利罗库单抗组和安慰剂组。平均随访时间是2.8年,主要终点事件是主要心血管不良事件(MACE),包括冠心病、非致死性心