Transl Psychiatry:研究发现:“认知行为疗法”强迫症患者的希望

2017-09-24 佚名 medicalnewstoday

研究人员在接受了一种认知行为疗法后,用脑部扫描来测量强迫症患者大脑活动的变化。他们发现,关键大脑网络的连接性得到了改善,这表明了这种治疗具有可行性。

研究人员在接受了一种认知行为疗法后,用脑部扫描来测量强迫症患者大脑活动的变化。他们发现,关键大脑网络的连接性得到了改善,这表明了这种治疗具有可行性。

强迫症是一种由无法逃避的、侵入性的想法所标记出来的,它会导致焦虑(因此是“强迫性的”),以及重复的、仪式性的行为,目的是减少这种感觉(因此是“强迫性的”)。

强迫症可能是一种衰弱的疾病,严重影响日常功能。美国国家心理健康研究所估计,在美国,每年OCD的患病率达到成年人口的1%。大约一半的病例被认为是“严重的”。

强迫症的治疗包括选择性5 -羟色胺再摄取抑制剂和认知行为疗法(CBT),这是一种旨在改善破坏性心理联想的疗法。

加州大学洛杉矶分校(University of California,Los Angeles)的研究人员,由杰米·弗斯纳(Jamie Feusner)博士领导,他们进行了一项研究,目的是研究CBT是否会改变被诊断为强迫症人的大脑活动和网络连接水平。

他们解释说,虽然CBT治疗强迫症的疗效之前已经被研究过,但这很可能是第一个使用功能性核磁共振成像(fMRI)来监测患有强迫症的人在接受这种治疗后大脑中实际发生的情况的研究。

研究人员的发现最近发表在《转化精神病学》杂志上。

CBT后关键脑区的变化

该小组特别针对暴露和反应预防(ERP)的CBT的影响,这需要暴露于刺激刺激和鼓励个人以正常的方式抵抗这些刺激物。
在这项研究中,43名患有强迫症和24人的人没有被招募。两组的结果比较后,没有OCD的24个个体作为对照组。
所有被诊断为OCD的参与者在每周5天的90分钟的疗程中接受了基于erpbased的CBT,总共4周。
两组的参与者都接受了核磁共振成像。接受CBT治疗的OCD患者在治疗前和4周的治疗后都进行了扫描。没有接受CBT治疗的对照组的参与者在4周后也进行了fMRI扫描。

当与OCD的参与者进行对比时,发现的结果与CBT之前的结果有很大的对比。

研究人员注意到,OCD患者的大脑在8个不同的大脑网络(包括小脑、尾状核和putamen)、背外侧和腹外侧前额皮质之间的连接显着增加。

小脑与加工信息有关,并决定自主运动,而尾状核和蛹则是学习过程和控制无意识冲动的关键。
背外侧和腹外侧前额皮质与计划动作和运动有关,以及调节某些认知过程。

Feusner博士和他的团队指出,大脑区域之间的连接水平的提高表明,接受认知行为治疗的人的大脑正在“学习”新的非强迫行为,并激活不同的思维模式。

他认为这些变化可能是解决强迫症认知和行为特性的新方法。

这些变化似乎是为了弥补,而不是正确的,潜在的大脑功能障碍。研究结果为未来的研究、新的治疗目标和新方法打开了大门。

杰米·福伊斯纳博士,第一项研究的作者,青少年穆迪博士补充说,在认知行为治疗后,大脑中有可量化的积极变化,这可能会给那些在适当的治疗后更有信心的人。

“研究结果可以给强迫症患者带来希望和鼓励,”穆迪博士说,“向他们展示CBT能在大脑中产生可测量的变化,与症状减轻相关。”

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    2018-04-17 bsmagic9140
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createdName=哈哈869, createdTime=Sun Sep 24 15:52:17 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-25 sunfeifeiyang

    学习.强迫治疗需要一个不短的过程

    0

  9. 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createdName=哈哈869, createdTime=Sun Sep 24 15:52:17 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-24 哈哈869

    已阅

    0

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