J Periodontol: P. gingivalis感染加重自身免疫性脑脊髓炎

2018-12-30 MedSci MedSci原创

用牙龈卟啉单胞菌口服感染小鼠诱导牙周炎症和附着丧失。本实验旨在研究用牙龈卟啉单胞菌感染小鼠是否会加剧实验性自身免疫性脑脊髓炎(EAE) - 多发性硬化症(MS)小鼠模型的临床过程。

用牙龈卟啉单胞菌口服感染小鼠诱导牙周炎症和附着丧失。本实验旨在研究用牙龈卟啉单胞菌感染小鼠是否会加剧实验性自身免疫性脑脊髓炎(EAE) - 多发性硬化症(MS)小鼠模型的临床过程。

方法:通过用髓鞘少突胶质细胞糖蛋白(MOG35-55)免疫C57BL / 6小鼠来进行EAE的诱导。通过皮下腔室模型和口服强饲法诱导牙龈卟啉单胞菌感染。使用临床严重性评分测量EAE的严重性。还测试了具有致脑炎肽MOG35-55的淋巴细胞的离体再活化。

结果:牙龈卟啉单胞菌的皮下和口腔感染导致EAE严重程度的显着恶化。在牙龈卟啉单胞菌感染后从具有EAE的小鼠收获的淋巴结细胞显示与仅具有EAE的小鼠相比,针对发生性的MOG部分的淋巴细胞增殖增加。

目前的结果表明,牙龈卟啉单胞菌的口腔感染增加了EAE的严重程度。这可能源于由牙龈卟啉单胞菌感染或通过抗原模拟引发的全身促炎反应。本研究提供的证据表明,牙周感染可能在中枢神经系统炎症性疾病如MS中发挥作用。

原始出处:

David Polak,et al.Oral infection with P. gingivalis exacerbates autoimmune encephalomyelitis.Journal of Periodontology.2018 Decemember. Doi:10.1002/JPER.17-0531

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    2019-09-14 xlysu
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    2019-08-11 feather89
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    2019-01-01 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

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    2018-12-30 王秀

    学习了,涨知识!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1650440, encodeId=3118165044056, content=<a href='/topic/show?id=b14384624a3' target=_blank style='color:#2F92EE;'>#脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84624, encryptionId=b14384624a3, topicName=脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06db24008155, createdName=xlysu, createdTime=Sat Sep 14 23:10:00 CST 2019, time=2019-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727823, encodeId=1d441e27823b2, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Aug 11 19:10:00 CST 2019, time=2019-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2080313, encodeId=5b7220803138f, content=<a href='/topic/show?id=e2bf8504282' target=_blank style='color:#2F92EE;'>#脑脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85042, encryptionId=e2bf8504282, topicName=脑脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Sat Oct 12 02:10:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356903, encodeId=cf2a356903f8, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Jan 01 12:34:25 CST 2019, time=2019-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356788, encodeId=170a356e88fa, content=学习了,涨知识!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Sun Dec 30 23:43:00 CST 2018, time=2018-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356783, encodeId=4ec7356e830f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sun Dec 30 23:25:54 CST 2018, time=2018-12-30, status=1, ipAttribution=)]
    2018-12-30 医者仁心5538

    学习了

    0