Dig Dis Sci:慢性胰腺炎患者骨相关疾病病的患病率和危险因素分析

2021-01-15 MedSci原创 MedSci原创

慢性胰腺炎(CP)是一种进行性胰腺纤维化炎症,最终会导致具有遗传或环境危险因素的个体胰腺外分泌和内分泌功能的不可逆转的丧失。

      慢性胰腺炎(CP)是一种进行性胰腺纤维化炎症,最终会导致具有遗传或环境危险因素的个体胰腺外分泌和内分泌功能的不可逆转的丧失,CP患者不仅会由于糖尿病,脂肪变性,体重减轻,腹部不适和其他临床表现而导致生活质量受损,而且还面临诸如代谢性骨病和低创伤性骨折等隐患的风险增加。

 

 

       代谢性骨病包括骨质疏松症和骨质减少。骨质疏松是一种涉及骨代谢受损的常见疾病;这会导致骨矿物质密度(BMD)降低和随后引起的骨折。迄今为止,尚无关于中国人群CP骨病患病率的数据。因此,本项研究旨在评估中国CP患者的骨病患病率和危险因素。

 

 

      本项研究是来自于中国一家大型医疗中心的CP患者的横断面研究。研究人员收集了2017年1月31日至2018年1月31日期间的CP患者的临床数据。对骨密度和实验室检查(包括与骨相关的生化,炎症和激素参数)进行前瞻性评估。分析了有骨病和没有骨病的患者之间的差异。使用逻辑回归分析来研究变量之间的关联。

 

 

 

      共有104名CP患者参加了这项研究(68.3%为特发性和31.7%为酒精性)。根据疾病分类,87.5%的患者处于疾病早期阶段(0–II)。30.8%的患者诊断为骨质减少症,5.8%的患者诊断为骨质疏松;因此,共有36.5%的患者出现骨病。在多因素分析中,CP患者的骨病独立危险因素为年龄(OR = 1.04; 95%CI = 1.00–1.08;P  = 0.030),BMI(OR = 0.72; 95%CI = 0.58–0.89;P  = 0.003 )和甲状旁腺素(PTH)(OR = 0.96; 95%CI = 0.93–1.00;P  = 0.022)。

 

 

      最后研究人员说道:这项研究是第一个报道中国CP患者骨病患病率的研究。研究发现,年龄和低BMI是引起骨病的重要危险因素。低PTH显示与骨病的关联较弱,但值得进一步探讨。

 

 

 

原始出处:

Xin-Ying Tang. Et al. Prevalence and Risk Factors for Osteopathy in Chronic Pancreatitis. Digestive Diseases and Sciences.2021.

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    2021-12-05 zhaojie88
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    2021-01-15 ms2000000457856676

    厉害

    0

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    2021-01-15 医鸣惊人

    认真学习了

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