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Clinica Chimica Acta：血清白介素-33作为重型颅脑损伤预后指标的有效性如何？

2019-11-23 gladiator MedSci原创

血清白介素-33重型颅脑损伤预后
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最近，白细胞介素-33被作为脑损伤的生物标志物。本研究检测了血清白细胞介素-33浓度是否与创伤性脑损伤(TBI)后的炎症、严重程度和预后相关。

最近，白细胞介素-33被作为脑损伤的生物标志物。本研究检测了血清白细胞介素-33浓度是否与创伤性脑损伤(TBI)后的炎症、严重程度和预后相关。

研究人员对 102健康对照组和102年的严重创伤性脑损伤的患者的血清浓度interlerukin-33以及102年严重的创伤性脑损伤的患者的3种炎症生物标志物的血清浓度(白细胞介素- 6、肿瘤坏死因子-α和c反应蛋白)和7个特异性蛋白质(髓磷脂碱性蛋白、胶质纤丝的星形胶质细胞蛋白质、S100B、特异性神经元烯醇酶、磷酸化轴突神经丝亚基H,τ和泛素羧基末端水解酶L1)。记录的不良预后变量包括急性肺损伤、急性创伤性凝血障碍、进行性出血损伤、创伤后脑梗死和6个月死亡率以及不良预后(格拉斯哥评分1-3)。

研究发现，于对照组相比，病例组的interlerukin-33浓度中位数(692 pg / mL)显著提高。Interlerukin-33浓度>> 692692pg / mL成为独立的预后指标，其鉴别能力超过了上述炎症生物标志物的浓度，且在GCS评分和上述细胞特异性蛋白浓度范围内。

研究表明，血清白细胞介素-33浓度升高可以反映TBI后的炎症、严重程度和较差的预后。

原始出处：

Zu-Yong Zhang，Jun Li，Usefulness of serum interleukin-33 as a prognostic marker of severe traumatic brain injury

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    2020-07-24 qblt

    #重型颅脑损伤#

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    2020-03-11 windight

    #CTA#

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    2019-11-25 budeshao

    #白介素#

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    2019-11-25 jwf_2001

    #预后指标#

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    2019-11-25 fengting3

    #颅脑损伤#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1633035, encodeId=e2e91633035d8, content=<a href='/topic/show?id=828795e2833' target=_blank style='color:#2F92EE;'>#重型颅脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95728, encryptionId=828795e2833, topicName=重型颅脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3fa21990661, createdName=qblt, createdTime=Fri Jul 24 21:00:00 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849787, encodeId=99ea1849e8745, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Mar 11 23:00:00 CST 2020, time=2020-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372130, encodeId=a2d113e213046, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Mon Nov 25 12:00:00 CST 2019, time=2019-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374183, encodeId=3b1813e4183b9, content=<a href='/topic/show?id=8de610018644' target=_blank style='color:#2F92EE;'>#预后指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100186, encryptionId=8de610018644, topicName=预后指标)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca3c375, createdName=jwf_2001, createdTime=Mon Nov 25 12:00:00 CST 2019, time=2019-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379965, encodeId=499213e9965b7, content=<a href='/topic/show?id=5f3c10046499' target=_blank style='color:#2F92EE;'>#颅脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100464, encryptionId=5f3c10046499, topicName=颅脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bcd469, createdName=fengting3, createdTime=Mon Nov 25 12:00:00 CST 2019, time=2019-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397866, encodeId=5f4d139e8666c, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Mon Nov 25 12:00:00 CST 2019, time=2019-11-25, status=1, ipAttribution=)]
    2019-11-25 ms3046638856685384

    #损伤#

    0