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Sci Signal：衰老减弱先天免疫功能的分子机制

2017-12-18 药明康德 学术经纬

IAV老年人RIG-I
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老年人（大于65岁）与年青人相比更容易因为感染A型流感病毒 (influenza A virus， IAV) 而去世。与年青人的单核细胞 (monocyte) 相比，老年人的单核细胞生产的干扰素 (interferons， IFNs)更少，而且IAV感染引发的抗病毒基因的表达也相对减弱。

老年人（大于65岁）与年青人相比更容易因为感染A型流感病毒 (influenza A virus， IAV) 而去世。与年青人的单核细胞 (monocyte) 相比，老年人的单核细胞生产的干扰素 (interferons， IFNs)更少，而且IAV感染引发的抗病毒基因的表达也相对减弱。耶鲁大学医学院 (Yale School of Medicine) 的研究人员发现老年人对IAV感染的先天免疫反应降低的原因是细胞质中发现IAV RNA的感受器RIG-I的下游信号通路发生了变化。在老年人的单核细胞中，媒介RIG-I信号通路的TRAF3蛋白含量下降，导致RIG-I信号通路引发的1型IFN表达下降。同时老年单核细胞不能有效激发IFN调控转录因子IRF8的表达，而IRF8对IFN在单核细胞中的表达有关键性作用。当研究人员在年轻人的单核细胞中敲除IRF8后，它们也表现出与老年单核细胞同样的IFN表达缺陷。而在老年单核细胞中恢复IRF8水平就足以恢复RIG-I引发的IFN反应。这项研究表明在老年人中恢复TRAF3的水平或者激发IRF8的表达可能是减少因IAV感染造成的死亡的一种潜在疗法。

原始出处：

Molony RD，et al.，Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes.Sci Signal. 2017 Dec 12；10(509). pii： eaan2392.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1793986, encodeId=f79f1e93986a8, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat Oct 20 18:26:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036163, encodeId=7010203616323, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Wed Jul 04 22:26:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270815, encodeId=63d02e081521, content=有意思，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Wed Dec 20 07:24:24 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513529, encodeId=0c78151352938, content=<a href='/topic/show?id=9293289e30d' target=_blank style='color:#2F92EE;'>#免疫功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28973, encryptionId=9293289e30d, topicName=免疫功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Dec 20 04:26:00 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585812, encodeId=b9001585812fc, content=<a href='/topic/show?id=4ec1285864b' target=_blank style='color:#2F92EE;'>#先天免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28586, encryptionId=4ec1285864b, topicName=先天免疫)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Dec 20 04:26:00 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270553, encodeId=60af2e0553c0, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Dec 19 09:29:25 CST 2017, time=2017-12-19, status=1, ipAttribution=)]
    2018-10-20 yaanren

    #Signal#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1793986, encodeId=f79f1e93986a8, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat Oct 20 18:26:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036163, encodeId=7010203616323, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Wed Jul 04 22:26:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270815, encodeId=63d02e081521, content=有意思，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Wed Dec 20 07:24:24 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513529, encodeId=0c78151352938, content=<a href='/topic/show?id=9293289e30d' target=_blank style='color:#2F92EE;'>#免疫功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28973, encryptionId=9293289e30d, topicName=免疫功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Dec 20 04:26:00 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585812, encodeId=b9001585812fc, content=<a href='/topic/show?id=4ec1285864b' target=_blank style='color:#2F92EE;'>#先天免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28586, encryptionId=4ec1285864b, topicName=先天免疫)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Dec 20 04:26:00 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270553, encodeId=60af2e0553c0, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Dec 19 09:29:25 CST 2017, time=2017-12-19, status=1, ipAttribution=)]
    2018-07-04 楚秀娟

    #Sign#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1793986, encodeId=f79f1e93986a8, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat Oct 20 18:26:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036163, encodeId=7010203616323, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Wed Jul 04 22:26:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270815, encodeId=63d02e081521, content=有意思，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Wed Dec 20 07:24:24 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513529, encodeId=0c78151352938, content=<a href='/topic/show?id=9293289e30d' target=_blank style='color:#2F92EE;'>#免疫功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28973, encryptionId=9293289e30d, topicName=免疫功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Dec 20 04:26:00 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585812, encodeId=b9001585812fc, content=<a href='/topic/show?id=4ec1285864b' target=_blank style='color:#2F92EE;'>#先天免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28586, encryptionId=4ec1285864b, topicName=先天免疫)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Dec 20 04:26:00 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270553, encodeId=60af2e0553c0, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Dec 19 09:29:25 CST 2017, time=2017-12-19, status=1, ipAttribution=)]
    2017-12-20 stupidox

    有意思，学习了。

    0

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    2017-12-20 zhaojie88

    #免疫功能#

    0

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    2017-12-20 仁心济世

    #先天免疫#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1793986, encodeId=f79f1e93986a8, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat Oct 20 18:26:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036163, encodeId=7010203616323, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Wed Jul 04 22:26:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270815, encodeId=63d02e081521, content=有意思，学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Wed Dec 20 07:24:24 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513529, encodeId=0c78151352938, content=<a href='/topic/show?id=9293289e30d' target=_blank style='color:#2F92EE;'>#免疫功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28973, encryptionId=9293289e30d, topicName=免疫功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Dec 20 04:26:00 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585812, encodeId=b9001585812fc, content=<a href='/topic/show?id=4ec1285864b' target=_blank style='color:#2F92EE;'>#先天免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28586, encryptionId=4ec1285864b, topicName=先天免疫)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Dec 20 04:26:00 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270553, encodeId=60af2e0553c0, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Dec 19 09:29:25 CST 2017, time=2017-12-19, status=1, ipAttribution=)]
    2017-12-19 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

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