Hypertension:体力活动、左心室质量、高血压与预后

2019-12-31 xing.T MedSci原创

总之,血压正常的个体在体育活动水平增加时左心室质量指数较高,而高血压患者这种关联并不存在。体力活动水平与更好的预后相关,而与是否存在左心室肥大无关。

左心室肥大是高血压预后的重要指标。体力活动与较大的左心室质量有关,但也降低了心血管结局的风险。近日,心血管权威杂志Hypertension上发表了一篇研究文章,该研究旨在探究(1)高血压是否会改变体力活动与左心室质量之间的联系;(2)左心室肥厚改变了体育活动与预后之间的有益联系。

研究人员从接受超声心动图检查的总人群中随机选择了3078人。左心室质量除以身体表面积。身体活动水平是由受试者自我报告:不活动、轻度活动和中度/高度活动。在休息时测量血压:正常BP(<140/90 mmHg)和高血压(≥140/90 mmHg或接受高血压药物治疗)。

高血压显著改变了体育活动与左心室质量指数之间的关联(交互作用检验:P=0.01):在正常血压中,较高的体育活动与左心室质量指数显著相关(P<0.001),但这在高血压患者中不存在(P=0.90)。体力活动水平与死亡率降低和心血管疾病预后相关,而与LVH的存在无关(LVH患者:轻度活动性HR为0.77 [0.52-1.15],中度/高活动性HR为0.61 [0.38-0.97]; LVH与身体活动水平之间的相互作用P=0.71)。

总之,血压正常的个体在体育活动水平增加时左心室质量指数较高,而高血压患者这种关联并不存在。体力活动水平与更好的预后相关,而与是否存在左心室肥大无关。

原始出处:

Gowsini Joseph.et al.Level of Physical Activity, Left Ventricular Mass, Hypertension, and Prognosis.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.14287

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