EUR HEART J:青少年的体重与早期心脏衰竭风险之间的关系

2017-06-26 MedSci MedSci原创

研究发现,在正常体重已经可以检测到早期心衰的风险大大增加,并且在最高体重者中这一风险增加了近10倍。考虑到目前肥胖症的流行,未来年轻人的心脏衰竭可能会大幅度增加,医生们需要意识到这一点。

目的:
研究年轻男性BMI与心脏衰竭早期住院风险的关系。

方法:
在一项前瞻性队列研究中,调查了1968 - 2005年期间来自瑞典征兵登记处的1610437名男子,平均年龄:18.6岁,随访5 - 42年(中位数,23.0年;四分间距:15.0 - 32.0),5492例首次住院治疗心衰[诊断时平均年龄为46.6(SD:8.0)]。

结果:
在对年龄、征兵年、合并症基线、父母教育、血压、智商、肌肉强度和体能等方面进行调整后,与BMI为18.5-20.0 kg/m2的男性相比,BMI 20.0-22.5 kg/m2的男性的危险比(HR)为1.22(95% CI:1.10-1.35)。随BMI增加,危险因素递增,BMI为30-35 kg/m2的男性的校正HR为6.47(95% CI:5.39-7.77);BMI≥35 kg/m2的男性HR为9.21(95% CI:6.57-12.92)。BMI每增加1个单位,心脏衰的多因素调整危险指数从1.06(95%CI:1.02-1.11,与瓣膜病相关的心力衰竭)到1.20(95% CI:1.18-1.22,与冠心病、糖尿病高血压相关)。

结论:
研究发现,在正常体重就已经可以检测到早期心衰的风险大大增加,并且在最高体重者中这一风险增加了近10倍。考虑到目前肥胖症的流行,未来年轻人的心脏衰竭可能会大幅度增加,医生们需要意识到这一点。

原始出处
Annika Rosengren, Mari Aberg, Josefina Robertson,et al. Body weight in adolescence and long-term risk of early heart failure in adulthood among men in Sweden. EUR HEART J. 2017 June.

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    2017-07-22 lofter

    学习了,感谢分享!

    0

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    2017-06-28 zhaojie88
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    2017-06-28 slcumt

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