Mater Sci Eng C Mater Biol Appl:双重治疗钴掺入的生物陶瓷加速骨组织再生

2019-03-22 不详 网络

由创伤或肿瘤引起的缺损的骨移植刺激骨再生,这是一个复杂的过程,需要高度协调的细胞信号相互作用。骨血管生长与骨生成相结合,但对血管生成和骨生成之间的相互作用知之甚少。了解这种关系与改善骨再生有关。在此,研究人员设计了掺杂不同浓度钴(联TCP)的磷酸三钙(TCP)支架,以研究血管形成对骨形成的剂量效应。结果显示,Coudy TCP,特别是2%和5%Co-TCP,增强了骨髓基质细胞(BMSC)的细胞活力

由创伤或肿瘤引起的缺损的骨移植刺激骨再生,这是一个复杂的过程,需要高度协调的细胞信号相互作用。骨血管生长与骨生成相结合,但对血管生成和骨生成之间的相互作用知之甚少。了解这种关系与改善骨再生有关。在此,研究人员设计了掺杂不同浓度钴(联TCP)的磷酸三钙(TCP)支架,以研究血管形成对骨形成的剂量效应。

结果显示,Coudy TCP,特别是2%和5%Co-TCP,增强了骨髓基质细胞(BMSC)的细胞活力。2%Co-TCP在体外促进BMSCs中的碱性磷酸酶活性,基质矿化和成骨基因的表达。然而,过量的Co掺杂减少了TCP诱导的骨生成。同时,Co-TCP剂量依赖性地促进人脐静脉内皮细胞(内皮细胞)的生长和迁移,以及血管内皮生长因子(VEGF)的表达。与TCP相比,2%的Co-TCP明显缩小大鼠牙槽骨中的缺损区。与2%Co-TCP相比,5%Co-TCP观察到较小的骨体积和更丰富的血管。5%Co-TCP组中的CD31免疫染色比其他两组更强烈,表明内皮细胞增加。此外,5%的Co-TCP在骨缺损区域导致轻度炎症反应。

总体而言,适当掺杂钴的TCP对成骨有积极作用,而过量的钴抑制成骨细胞分化和骨形成。这些数据表明在适当范围内的血管形成促进骨生成,这可能是骨移植的设计考虑因素。

原始出处:

Zheng Y, Yang Y, Deng Y. Dual therapeutic cobalt-incorporated bioceramics accelerate bone tissue regeneration. Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:770-782. doi: 10.1016/j.msec.2019.02.020. Epub 2019 Feb 7.

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    2019-04-27 sunylz
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  5. 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    2019-11-13 spoonycyy
  6. 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GetPortalCommentsPageByObjectIdResponse(id=363402, encodeId=fa8636340282, content=好好好(, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Mar 23 07:00:19 CST 2019, time=2019-03-23, status=1, ipAttribution=)]
    2019-05-22 redcrab
  7. 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GetPortalCommentsPageByObjectIdResponse(id=363402, encodeId=fa8636340282, content=好好好(, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Mar 23 07:00:19 CST 2019, time=2019-03-23, status=1, ipAttribution=)]
    2019-03-28 清风拂面

    谢谢分享学习

    0

  8. 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  9. 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    2019-03-23 yjs木玉

    好好好好好好

    0

  10. 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    2019-03-23 yjs木玉

    好好好(

    0