2019年CROI:异烟肼疗法可预防艾滋病毒感染孕妇的结核病

2019-03-11 不详 网络

根据2019年逆转录病毒和机会性感染会议(CROI)上的一项研究结果,异烟肼治疗似乎对已被诊断患有艾滋病的准妈妈的结核病预防是安全的。

根据2019年逆转录病毒和机会性感染会议(CROI)上的一项研究结果,异烟肼治疗似乎对已被诊断患有艾滋病的准妈妈的结核病预防是安全的。

约翰霍普金斯医学院医学博士Nicole Salazar-Austin表示:怀孕和艾滋病毒都会增加结核病的风险。即使我们考虑到其他因素导致更糟糕的结果,例如晚期艾滋病毒、高龄孕妇和怀孕期间体重增加较低,这些结果仍然适用Salazar-Austin博士及其同事从前瞻性真实世界Tshepiso研究(2011-2014)中提取患者,该研究评估了患有和未患有活动性肺结核的HIV孕妇的母婴结局,异烟肼预防疗法由产前和艾滋病诊所启动,而不是由该研究启动。

异烟肼对结核杆菌有强大的抑菌至杀菌作用,也作用于细胞内的杆菌;毒性小,易吸收,穿透性强,用于各种类型的结核病;单用容易产生抗药性,常与对氨基水杨酸盐或链霉素合用。


原始出处:

http://www.firstwordpharma.com/node/1628634#axzz5houfIuVA

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