Prostate Cancer P D:生化复发前列腺癌中单胺氧化酶抑制剂phenelzine的2期试验研究

2020-03-22 AlexYang MedSci原创

在预临床模型中,单胺氧化酶A(MAOA)能够影响前列腺癌的生长和转移。最近,有研究人员调查了phenelzine(一种单胺氧化酶抑制剂)在生化复发去势敏感性前列腺癌患者中的效果情况。

在预临床模型中,单胺氧化酶A(MAOA)能够影响前列腺癌的生长和转移。最近,有研究人员调查了phenelzine(一种单胺氧化酶抑制剂)在生化复发去势敏感性前列腺癌患者中的效果情况。

研究是一个开放标签的单臂临床试验,招募了生化复发前列腺癌患者,这些患者在根治性前列腺切除后PSA≥0.4ng/ml或者放疗后PSA≥2ng/ml;成像不显示存在转移且雄激素水平正常。受试者每两天口服30mg的phenelzine。研究共包括了20名符合要求的患者,平均年龄为66.9±4.8岁,PSA为4.7±5.8ng/dl。PSA最高减少≥30%和≥50%的分别占比25%(n=5)和10%(n=2)。在第12周,继续治疗的17名受试者中PSA减少≥30%和≥50%的分别占比24%(n=4/17)和6%(n=1/17)。常见的毒性作用包括头晕(1级=45%,2级=35%),高血压(不小于2级=30%)和水肿(1级=25%,2级=10%)。有1例4级高血压(第4周期)和2例3级晕厥(第12周期和第14周期)需要停止治疗。医院焦虑抑郁评分(HADS)调查问卷表明焦虑显著减少,而治疗中的抑郁症状没有变化。

最后,研究人员指出,phenelzine在生化复发去势敏感前列腺癌患者中是有治疗效果的。大多数治疗相关的毒性上轻微的,但也观察到了罕见的显著且可逆的心血管毒性事件。靶向MAOA的治疗也许是复发前列腺癌患者的新方法。

原始出处:

Mitchell E. Gross, David B. Agus, Tanya B. Dorff et al. Phase 2 trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer. Prostate Cancer P D. 03 Mar 2020

 

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    2021-01-09 jklm09
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    2020-03-24 lsndxfj
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    2020-03-24 sunylz
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    2020-03-22 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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