Gastroenterology:肝硬化对于孕妇及其婴儿结局的影响

2020-09-12 MedSci原创 MedSci原创

有研究报道,育龄妇女的肝硬化发病率正在增加。我们都知道肝脏对于我们生命活动来说是至关重要的,肝硬化会严重影响到我们的生命活动。孕妈更是如此。

        有研究报道,育龄妇女的肝硬化发病率正在增加。我们都知道肝脏对于我们生命活动来说是至关重要的,肝硬化会严重影响到我们的生命活动。孕妈更是如此。那么,孕妇肝硬化可以顺产吗?孕妇肝硬化怎么办呢? 本项研究旨在探究肝硬化与围产期结局之间的关联。

 

        研究人员使用来自加拿大安大略省(2000-2017年)的医疗数据进行了一项回顾性队列研究,使用经过验证的病例定义确定了患有代偿性肝硬化的孕妇 2022名,再根据出生年份和社会经济状况,将这些妇女与总人口中的10110名孕妇(1:5)匹配,最后使用多元对数二项式回归评估产后6周的母婴结局以及产后1年的肝相关并发症。

 

        在调整了人口统计学和代谢危险因素后,肝硬化与妊娠肝内胆汁淤积症独立相关(相对危险度[RR],10.64,95%CI,7.49-15.12),引产也是独立相关(RR,1.15; 95%CI,1.03–1.28),以及和产褥期感染(RR,1.32; 95%CI,1.02-1.70),早产(RR,1.60; 95%CI,1.35-1.89),大胎龄儿(RR,1.24;–1.03。 95%CI,1.05-1.46)和新生儿呼吸窘迫(RR,1.20; 95%CI,1.02-1.42)有关。少于2%的肝硬化孕妇有与肝有关的并发症,但这些发生在有肝代偿失调史的妇女中(13%)的比例明显高于代偿性肝硬化的妇女(1.2%)(P <.001) 。

 

        因此,通过这项研究研究人员发现肝硬化是围产期不良后果的独立危险因素。但是,与肝脏相关的并发症很少见。

 

原始出处:

Jennifer A.Flemming. Et al. Outcomes of Pregnant Women With Cirrhosis and Their Infants in a Population-Based Study. Gastroenterology.2020.

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    2021-06-26 许安
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    2020-09-23 152op209450

    学习了

    0

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    2020-09-13 lovetcm

    #育龄妇女##肝硬化#发病率正在增加,原因何在?

    0

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    2020-09-13 guging

    谢谢!最新的信息读起来就是收获大

    0

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