Stroke:脑出血前的认知障碍与脑淀粉样血管病相关!

2017-12-16 xing.T MedSci原创

由此可见,经磁共振成像标记确定的CAA与症状性ICH前认知功能下降有关。这提供了证据表明CAA中的小血管破裂除了ICH直接导致的脑损伤外,还对认知功能障碍有独立的作用。

虽然脑淀粉样血管病(CAA)和认知障碍之间的关联越来越受到认可,目前尚不清楚这是否是因为复发性脑出血(ICH)事件、脑小血管损伤引起的破裂或两者均参与的影响。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员评估了ICH前认知障碍是否与磁共振成像上的CAA影像学特征有关。

研究人员对166例脑影像学确诊的ICH患者进行了前瞻性多中心观察性研究。利用老年人认知功能下降知情者问卷(IQCODE)来确定认知功能障碍。通过训练有素的观察员根据指南共识来评估包括CAA在内的脑小血管疾病的磁共振成像标记。

ICH前认知障碍的患病率为24.7%(n=41),在调整后的分析中,ICH前认知障碍与符合修改后的波士顿CAA标准(比值比为4.01;95%可信区间为1.53-10.51;P=0.005)和较高的复合CAA评分(每增加一点的比值比为1.42;95%可信区间为1.03-1.97;P=0.033)相关。研究人员还发现ICH前的认知能力下降与皮质表面铁沉积、严格脑叶微出血以及脑叶出血位置之间存在独立相关性,但与其他神经影像学标志或复合小血管疾病评分无关。

由此可见,经磁共振成像标记确定的CAA与症状性ICH前认知功能下降有关。这提供了证据表明CAA中的小血管破裂除了ICH直接导致的脑损伤外,还对认知功能障碍有独立的作用。

原始出处:

Gargi Banerjee,et al. Cognitive Impairment Before Intracerebral Hemorrhage Is Associated With Cerebral Amyloid Angiopathy.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.117.019409

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2046660, encodeId=95b12046660a0, content=<a href='/topic/show?id=9b708491280' target=_blank style='color:#2F92EE;'>#脑淀粉样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84912, encryptionId=9b708491280, topicName=脑淀粉样)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dab8203, createdName=zsyan, createdTime=Mon Jun 25 11:17:00 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1644623, encodeId=46561644623f6, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Fri Jun 08 19:17:00 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320890, encodeId=ec233208906e, content=怎样收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/6I4kVApzPtk3VY4rl3Bshfp7ibY5K2WFTe52gs6qhx1umWTTqIstFWjWojicibmzUiaSycpRYBpcxicJv0yxRjfKjEQ/132, createdBy=cb112371516, createdName=飞雁出发, createdTime=Sat Jun 02 18:38:23 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628773, encodeId=be4c1628e732c, content=<a href='/topic/show?id=1c748491616' target=_blank style='color:#2F92EE;'>#脑淀粉样血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84916, encryptionId=1c748491616, topicName=脑淀粉样血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac7921195890, createdName=Smile2687, createdTime=Mon Dec 18 01:17:00 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269874, encodeId=9d4e2698e4ad, content=学习了.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat Dec 16 15:25:57 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2046660, encodeId=95b12046660a0, content=<a href='/topic/show?id=9b708491280' target=_blank style='color:#2F92EE;'>#脑淀粉样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84912, encryptionId=9b708491280, topicName=脑淀粉样)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dab8203, createdName=zsyan, createdTime=Mon Jun 25 11:17:00 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1644623, encodeId=46561644623f6, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Fri Jun 08 19:17:00 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320890, encodeId=ec233208906e, content=怎样收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/6I4kVApzPtk3VY4rl3Bshfp7ibY5K2WFTe52gs6qhx1umWTTqIstFWjWojicibmzUiaSycpRYBpcxicJv0yxRjfKjEQ/132, createdBy=cb112371516, createdName=飞雁出发, createdTime=Sat Jun 02 18:38:23 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628773, encodeId=be4c1628e732c, content=<a href='/topic/show?id=1c748491616' target=_blank style='color:#2F92EE;'>#脑淀粉样血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84916, encryptionId=1c748491616, topicName=脑淀粉样血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac7921195890, createdName=Smile2687, createdTime=Mon Dec 18 01:17:00 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269874, encodeId=9d4e2698e4ad, content=学习了.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat Dec 16 15:25:57 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2046660, encodeId=95b12046660a0, content=<a href='/topic/show?id=9b708491280' target=_blank style='color:#2F92EE;'>#脑淀粉样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84912, encryptionId=9b708491280, topicName=脑淀粉样)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dab8203, createdName=zsyan, createdTime=Mon Jun 25 11:17:00 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1644623, encodeId=46561644623f6, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Fri Jun 08 19:17:00 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320890, encodeId=ec233208906e, content=怎样收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/6I4kVApzPtk3VY4rl3Bshfp7ibY5K2WFTe52gs6qhx1umWTTqIstFWjWojicibmzUiaSycpRYBpcxicJv0yxRjfKjEQ/132, createdBy=cb112371516, createdName=飞雁出发, createdTime=Sat Jun 02 18:38:23 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628773, encodeId=be4c1628e732c, content=<a href='/topic/show?id=1c748491616' target=_blank style='color:#2F92EE;'>#脑淀粉样血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84916, encryptionId=1c748491616, topicName=脑淀粉样血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac7921195890, createdName=Smile2687, createdTime=Mon Dec 18 01:17:00 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269874, encodeId=9d4e2698e4ad, content=学习了.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat Dec 16 15:25:57 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2018-06-02 飞雁出发

    怎样收藏

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2046660, encodeId=95b12046660a0, content=<a href='/topic/show?id=9b708491280' target=_blank style='color:#2F92EE;'>#脑淀粉样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84912, encryptionId=9b708491280, topicName=脑淀粉样)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dab8203, createdName=zsyan, createdTime=Mon Jun 25 11:17:00 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1644623, encodeId=46561644623f6, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Fri Jun 08 19:17:00 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320890, encodeId=ec233208906e, content=怎样收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/6I4kVApzPtk3VY4rl3Bshfp7ibY5K2WFTe52gs6qhx1umWTTqIstFWjWojicibmzUiaSycpRYBpcxicJv0yxRjfKjEQ/132, createdBy=cb112371516, createdName=飞雁出发, createdTime=Sat Jun 02 18:38:23 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628773, encodeId=be4c1628e732c, content=<a href='/topic/show?id=1c748491616' target=_blank style='color:#2F92EE;'>#脑淀粉样血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84916, encryptionId=1c748491616, topicName=脑淀粉样血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac7921195890, createdName=Smile2687, createdTime=Mon Dec 18 01:17:00 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269874, encodeId=9d4e2698e4ad, content=学习了.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat Dec 16 15:25:57 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2046660, encodeId=95b12046660a0, content=<a href='/topic/show?id=9b708491280' target=_blank style='color:#2F92EE;'>#脑淀粉样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84912, encryptionId=9b708491280, topicName=脑淀粉样)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dab8203, createdName=zsyan, createdTime=Mon Jun 25 11:17:00 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1644623, encodeId=46561644623f6, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Fri Jun 08 19:17:00 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320890, encodeId=ec233208906e, content=怎样收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/6I4kVApzPtk3VY4rl3Bshfp7ibY5K2WFTe52gs6qhx1umWTTqIstFWjWojicibmzUiaSycpRYBpcxicJv0yxRjfKjEQ/132, createdBy=cb112371516, createdName=飞雁出发, createdTime=Sat Jun 02 18:38:23 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628773, encodeId=be4c1628e732c, content=<a href='/topic/show?id=1c748491616' target=_blank style='color:#2F92EE;'>#脑淀粉样血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84916, encryptionId=1c748491616, topicName=脑淀粉样血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac7921195890, createdName=Smile2687, createdTime=Mon Dec 18 01:17:00 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269874, encodeId=9d4e2698e4ad, content=学习了.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat Dec 16 15:25:57 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2017-12-16 明天会更好!

    学习了.学习了.

    0

相关资讯

Neurology:脑淀粉样血管病和高血压性小血管病腔隙分布有何差异?

由此可见,脑叶腔隙与CAA相关,而深部的腔隙在HTN-SVD患者中更频繁。脑叶腔隙似乎与WMH关系密切,提示它们可能有共同的起源。

Stroke:不同类型的脑小血管病的皮质表面铁沉积症!

由此可见,cSS在CADASIL患者中是不存在的,而其他的小血管病变的影像学特征与有cSS的CAA患者相似。该研究结果表明cSS结合其他小血管疾病的影像学标记对CAA具有高度指示性价值。

Neurology:淀粉-PET诊断CAA

皮层或软脑膜血管进展性β-淀粉沉积,比如脑淀粉样血管病(CAA),是老年人自发脑叶脑内出血和年龄相关认知功能损害的主要原因。神经病理样本或Boston标准中MRI脑叶出血的特征有助于诊断CAA,并且CAA的诊断呈逐渐增加的趋势。目前核磁作为诊断CAA的无创工具,已经被广泛应用。然而,核磁上检测到的脑局部损害仅仅是CAA的间接证据,是CAA的结果。识别早期阶段的CAA是非常困难的,比如出现MR多发病

CAA 2014:近三千名麻醉领域专家齐聚申城共赴麻醉盛会

2014年4月19日,一年一度的麻醉届盛会,2014年中国医师协会麻醉学医师分会年会(以下简称CAA 2014)在上海隆重拉开了帷幕,为全国麻醉医师带来了一场丰盛的学术饕餮盛宴。本届会议为期两天,全国共三千余名麻醉医师参加了本次大会。 大会现场一 大会现场二 大会现场三 新闻发布会现场 本届会议严肃而隆重的开幕式后,举办

CAA 2014 :祝贺王景阳与吴新民教授获终身成就奖

热烈祝贺王景阳教授与吴新民教授 荣获第八届新晨杯中国医师协会麻醉学医师终身成就奖 2014年4月19日,在隆重召开的中国医师协会麻醉学医师分会大会开幕式上,著名麻醉学专家,第二军医大学附属长海医院麻醉科开拓者,全军麻醉奠基人之一王景阳老教授以及英国皇家麻醉院名誉院士、北京大学第一医院麻醉科吴新民教授被授予第八届“新晨杯”中国医师协会麻醉学医师终身成就奖。中国医师协会会长张雁灵和中国科学院院士