JACC:综述:抗血小板药治疗和预防冠状动脉粥样硬化

2017-11-03 吴刚 环球医学

2017年10月,意大利、葡萄牙和英国等国科学家在《J Am Coll Cardiol》发表了抗血小板药治疗和预防冠状动脉粥样硬化的综述

2017年10月,意大利、葡萄牙和英国等国科学家在《J Am Coll Cardiol》发表了抗血小板药治疗和预防冠状动脉粥样硬化的综述。

抗血小板药物是急性缺血综合征(冠脉和脑血管管理预防复发的抗血栓治疗的一线用药。由于抗血小板药与其他预防策略联合时,其潜在获益和风险的平衡存在不确定性,因此抗血小板药在动脉粥样硬化血栓形成一级预防中的作用仍有争议。本综述的目的为,综述抗血小板药的有效性和安全性证据,基于合并症和/或干预措施,为心血管医师提供更新的工具,帮助他们为不同临床表现的冠状动脉血栓形成患者选择最合适的抗血小板策略。

本综述对于不同类别抗血小板药物的临床药理学及作用靶点等进行了详细综述,对抗血小板治疗单药预防的一级预防和二级预防的现状、未来的挑战进行了描述。同时,对抗血小板联合治疗的不同组合方案,如阿司匹林和氯吡格雷、阿司匹林和替格瑞洛、以替格瑞洛为基础的方案以及其他联合方案进行综述。此外,还对出血风险的预测、特殊人群用药监测、停用抗血小板治疗和桥接治疗的不同情况进行了描述和分析。

原始出处:

Patrono C,et al.,Antiplatelet Agents for the Treatment and Prevention of Coronary Atherothrombosis.J Am Coll Cardiol. 2017 Oct 3;70(14):1760-1776.

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    2018-08-30 hbwxf
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