Exp Ther Med:脂联素在诊断肾功能不全的急性心力衰竭中具有重要价值

2020-03-01 不详 网络

急性心力衰竭(AHF)由于其高发和预后不良而成为主要的公共卫生问题。因此,有效和及时的诊断对于改善预后和降低死亡率至关重要。氨基末端脑钠肽(NT-proBNP)被广泛用于AHF的诊断。然而,在诊断肾功能不全的AHF时,其疗效尚存争议。有大量研究报告了脂联素(ADPN)与心脏病的关系。因此,本研究旨在调查ADPN是否有助于鉴别肾功能不全的AHF。研究共纳入407名参与者(218名AHF患者和189名

急性心力衰竭(AHF)由于其高发和预后不良而成为主要的公共卫生问题。因此,有效和及时的诊断对于改善预后和降低死亡率至关重要。氨基末端脑钠肽(NT-proBNP)被广泛用于AHF的诊断。然而,在诊断肾功能不全的AHF时,其疗效尚存争议。有大量研究报告了脂联素(ADPN)与心脏病的关系。因此,本研究旨在调查ADPN是否有助于鉴别肾功能不全的AHF。

研究共纳入407名参与者(218名AHF患者和189名对照)。分别使用夹心酶联免疫吸附测定和电化学发光免疫测定来测量ADPN和NT-proBNP的血浆水平。此外,在纽约健康协会的各个类别以及缺血性和非缺血性AHF病例中比较了这些水平。通过Spearman相关性分析了这两种生物标志物与肾功能之间的相关性,同时评估了有无肾功能不全的AHF患者中ADPN和NT-proBNP的诊断效率。

结果显示,在无肾功能不全的患者中,NT-proBNP与ADPN相比显示出更高的诊断效率[接受者工作特征曲线下的面积(AUC),0.905 vs. 0.775]。相比之下,在肾功能不全的AHF中,ADPN比NT-proBNP具有更好的诊断价值(AUC,0.872 vs. 0.828)。因此,这两种生物标记物的组合可在诊断患有肾功能不全的AHF中提供出色的疗效(AUC,0.904;敏感性,71.2%;特异性,98.3%)。

总之,ADPN是诊断AHF的重要生物标志物,尤其是在肾功能受损的患者中。

原始出处:

Zhang Dai, Yan Zhang, et al., Adiponectin is valuable in the diagnosis of acute heart failure with renal insufficiency. Exp Ther Med. 2018 Sep; 16(3): 2725–2734.  doi: 10.3892/etm.2018.6511

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