J Biomed Mater Res A:镁掺杂钛植体可增强种植体周软组织封闭

2019-10-14 不详 网络

钛(Ti)植入物广泛用于种植体的制造。然而,种植体周围炎一直是最常见,最严重的并发症之一。在这里,我们证明了镁掺杂将是增强植入物表面和牙龈组织之间整合的有效方法,这对植入物周围的健康至关重要。通过镁等离子体浸没离子注入(Mg-PIII)技术将镁(2.76-6.35at.%)固定在钛基底上。Mg-PIII处理不会改变原始钛基材的表面形貌,但改善了其亲水性。体外研究结果显示,掺杂镁的钛改善了人牙龈成纤

钛(Ti)植入物广泛用于种植体的制造。然而,种植体周围炎一直是最常见,最严重的并发症之一。在这里,我们证明了镁掺杂将是增强植入物表面和牙龈组织之间整合的有效方法,这对植入物周围的健康至关重要。

通过镁等离子体浸没离子注入(Mg-PIII)技术将镁(2.76-6.35at.%)固定在钛基底上。Mg-PIII处理不会改变原始钛基材的表面形貌,但改善了其亲水性。体外研究结果显示,掺杂镁的钛改善了人牙龈成纤维细胞(HGF)的黏附,增殖,迁移及ECM重塑能力。蛋白质印迹的结果表明,Mg修饰的钛通过PI3K的激活诱导了AKT的磷酸化。

总之,该研究结果表明,镁掺杂可能通过以剂量依赖的方式促进HGF的细胞功能来增强软组织的封闭,这预示着其在早期种植体周围软组织整合中在种植体颈部表面的应用。

原始出处:

Zhu Y, Zhang CN, et al., The responses of human gingival fibroblasts to magnesium-doped titanium. J Biomed Mater Res A. 2019 Oct 13. doi: 10.1002/jbm.a.36813. 

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    2020-02-26 30397613
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    2020-02-23 sunylz
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    2020-02-16 huangdf
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