BMJ:富血小板血浆注射疗法可以有效治疗急性跟腱断裂

2020-01-27 不详 MedSci原创

本项研究旨在确定是否注射富含血小板的血浆可以改善急性跟腱断裂后的预后。

背景及目的:
本项研究旨在确定是否注射富含血小板的血浆可以改善急性跟腱断裂后的预后。

方法:
研究人员收集了2015年7月到2018年3月间英国19家医疗机构因急性跟腱断裂就诊的临床数据,其中包括230名18岁及以上的成年人,所有急性跟腱断裂在受伤后12天内,并接受了非手术治疗。干预措施为参与者以1:1的比例随机分配至富含血小板的血浆(n = 114)或安慰剂(n = 116)注射。所有参与者均接受了标准的康复护理(固定踝关节,然后进行理疗)。主要观察结局为24周时的肌腱功能,以脚后跟耐力测试中最大工作量的肢体对称性指标(受伤/未受伤×100)客观测量。次要结果包括患者报告的功能(跟腱断裂评分),生活质量,疼痛(视觉模拟评分),目标达成(患者特定功能评分)和不良事件。中央实验室分析了富含血小板血浆的质量和含量。

结果:
本项研究的参与者平均年龄为46岁。在第24周,有202名(88%)的参与者完成了脚跟抬起耐力测试,有216名(94%)的患者报告了结局。接受富含血小板的血浆注射的患者的预后良好,具有预期的生长因子含量。接受富血小板血浆注射的参与者与接受安慰剂注射的参与者之间的肌腱功能未检测到差异(肢体对称指数,平均34.7%(标准偏差17.7%)v 38.5%(22.8%))

结论:
与安慰剂相比,注射富含血小板的血浆可以改善急性跟腱断裂后的客观肌腱功能。

原始出处:

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    2020-05-09 gaoxiaoe
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