PNAS:瘦素(leptin)可能治疗下丘脑性闭经

2011-04-05 MedSci原创 MedSci原创

MedSci评论:瘦素(leptin)原来认为是最有希望用于治疗肥胖病的药物,但是在2009年前后,宣布临床研究失败。一方面减肥效果不明显,二还可以导致较为严重的心脏副作用。而这一篇报道,是将瘦素(leptin)用于其它的可能疾病的治疗研究上。这里应用于下丘脑闭经,但是这仅是临床试验的结果。  美国一项研究发现,增加瘦素水平可能有朝一日帮助因为过度锻炼或严重热量限制而闭经的女性。研究报告4月3日

MedSci评论:瘦素(leptin)原来认为是最有希望用于治疗肥胖病的药物,但是在2009年前后,宣布临床研究失败。一方面减肥效果不明显,二还可以导致较为严重的心脏副作用。而这一篇报道,是将瘦素(leptin)用于其它的可能疾病的治疗研究上。这里应用于下丘脑闭经,但是这仅是临床试验的结果。

 美国一项研究发现,增加瘦素水平可能有朝一日帮助因为过度锻炼或严重热量限制而闭经的女性。研究报告4月3日在线发表在《美国国家科学院院刊》(PNAS)上。

  美国哈佛医学院Christos Mantzoros及其同事进行了一场临床试验,从而确定瘦素替代对患下丘脑性闭经(HA)的女性的作用。下丘脑性闭经(HA)是一种内分泌疾病,它关闭了月经周期,并引发了相关健康问题,诸如不育和骨质疏松症。由脂肪细胞分泌的瘦素帮助调控人体的能量供应,此前的研究已经显示,患下丘脑性闭经(HA)的女性长期精力不足、血清瘦素浓度低。在一个双盲研究中,这组科研人员向20名患下丘脑性闭经(HA)的女性随机提供了安慰剂或一种合成瘦蛋白,称为美曲普汀。这组作者报告说,大70%的女性在这个为期36周的试验中对这种疗法有响应,有响应者中的4人有排卵。此外,用美曲普汀加以治疗的女性的骨形成生化标记血清水平比对照组更高。这组作者说,这项研究表明了瘦素缺乏引起下丘脑性闭经(HA),还证明了激素替代疗法可以用于治疗这种疾病。

  这组作者警告说,需要进行更大、更长期的试验来证实这些发现并确认该疗法的安全性。

  相关链接:Leptin is an effective treatment for hypothalamic amenorrhea  PNAS April 4, 2011

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    2011-04-17 drwjr
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    2011-04-07 sodoo
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    2011-04-07 xlwang2696
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    2011-04-07 xlwang2696