Int Forum Allergy Rhinol:慢性鼻炎中鼻后神经冷冻消融术后鼻漏预测因子研究

2020-06-08 AlexYang MedSci原创

鼻后神经(PNN)冷冻消融在改善过敏性和非过敏性(NAR)引起的鼻漏方面很有前景。早期的案例表明能够改善75%-80%的患者症状,但是预测PNN冷冻消融成功的预测因子还未有研究。最近,有研究人员评估了

鼻后神经(PNN)冷冻消融在改善过敏性和非过敏性(NAR)引起的鼻漏方面很有前景。早期的案例表明能够改善75%-80%的患者症状,但是预测PNN冷冻消融成功的预测因子还未有研究。最近,有研究人员评估了是否疾病特性和异丙托品喷鼻剂响应能够预测PNN冷冻消融术后的鼻漏响应。

研究是一个多单位的回顾性案例对照研究,包括了55名经历了PNN冷冻消融的患者。受试者平均年龄为55.3岁,54.65的为女性。随访均值为170天。NAR患者占比62%。研究发现,48名使用试验性异丙托品喷雾剂的患者中,33名(69%)存在一些相应,15名(31%)患者没有响应。术前总的流鼻评分(RNS)均值为4.2±1.0。PNN冷冻消融后,39名(71%)患者的RNS均有≥1点的减少。只有那些异丙托品喷雾剂(INS)存在响应的患者能够预测冷冻消融术的成功。对那些异丙托品喷雾剂响应的受试者中,28/33(85%)的受试者冷冻消融后RNS有所改善,而5/15的非响应者RNS具有改善(p=0.001)。

最后,研究人员指出,慢性鼻炎患者中,鼻漏对异丙托品的响应能够预测PNN冷冻消融后的鼻漏改善情况。他们的研究对于术前咨询和指导患者预期具有重要的应用。

原始出处:

Frederick Yoo , Edward C Kuan , Pete S Batra et al. Predictors of Rhinorrhea Response After Posterior Nasal Nerve Cryoablation for Chronic Rhinitis. Int Forum Allergy Rhinol. 22 May 2019.

 

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    2020-06-10 膀胱癌
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