Sci Rep:子宫内膜异位阶段3/4女性与健康女性阴道、子宫颈和肠道菌群比较研究

2019-03-05 AlexYang MedSci原创

生殖道中的生态失调或者肠道微生物的失调与女性子宫内膜异位相关。最近,有研究人员在组织病理学证明患有子宫内膜异位阶段3/4女性与14名健康女性对照中,比较了阴道、子宫颈和肠道菌群。研究人员根据16S宏基因组测序文库准备方法扩增了16S rRNA基因的V3和V4区域,并进行了比较。研究发现,尽管阴道、子宫颈和肠道菌群在子宫内膜异位阶段3/4女性与14名健康女性对照中总体相似,但是在属水平常具有差异。奇

生殖道中的生态失调或者肠道微生物的失调与女性子宫内膜异位相关。最近,有研究人员在组织病理学证明患有子宫内膜异位阶段3/4女性与14名健康女性对照中,比较了阴道、子宫颈和肠道菌群。

研究人员根据16S宏基因组测序文库准备方法扩增了16S rRNA基因的V3和V4区域,并进行了比较。研究发现,尽管阴道、子宫颈和肠道菌群在子宫内膜异位阶段3/4女性与14名健康女性对照中总体相似,但是在属水平常具有差异。奇异菌属在子宫内膜异位阶段3/4女性阴道菌落和子宫颈菌落中完全缺失,并且非常值得注意。在子宫颈菌落中,加德纳菌、链球菌、大肠杆菌、志贺氏菌和脲浆菌都包含潜在的致病种类,并且在子宫内膜异位阶段3/4患者中数量增加。另外,更多的子宫内膜异位阶段3/4患者具有志贺氏菌/大肠杆菌为主的粪便微生物组。

最后,研究人员指出,进一步的研究需要鉴定是否上述结果与子宫内膜异位是有相关性的,以及是否是生态失调导致子宫内膜异位还是子宫内膜异位导致生态失调。

原始出处:


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    2019-03-07 一闲

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最近由昆士兰大学的研究者们进行的一项有关子宫内膜异位疾病的大型遗传学研究结果揭示:5种基因的路边可能导致该疾病的发生。这项研究一共分析了20万女性的基因组构成,用于寻找引发子宫内膜异位的遗传学机制,这一发现将有助于未来相关治疗得开发。子宫内膜异位影响着十分之一的女性群体,该疾病会导致严重的盆腔疼痛、生育问题以及肠胃或膀胱的异常。

“大姨妈”来临时为什么会那么痛?

"大姨妈" 似乎是所有女性的心头梦魇,但不同女性的经历却各有差异。对于某些个体来说,这段时间能够轻松无痛地度过,但对于另外一些人来说则完全不同。至少大部分女性在其中的一到两天内都会有抓狂的心情,这也实属正常。相比成年女性,尤其是有孩子的女性来说,青春期的少女承受的痛苦可能更为强烈。但即使如此