CLIN CANCER RES:TGFβ1基因变异预测HPV阳性口咽癌患者根治性放疗后临床结局

2018-05-18 MedSci MedSci原创

TGFβ1在炎症反应,免疫反应,治疗反应和患者预后中起到关键作用。TGFβ1变异可能会影响其表达水平或功能,从而调节肿瘤状态,影响HPV阳性口咽鳞状细胞癌(SCCOP)患者生存。CLIN CANCER RES近期发表了一篇文章研究这一问题。

TGFβ1在炎症反应,免疫反应,治疗反应和患者预后中起到关键作用。TGFβ1变异可能会影响其表达水平或功能,从而调节肿瘤状态,影响HPV阳性口咽鳞状细胞癌(SCCOP)患者生存。CLIN CANCER RES近期发表了一篇文章研究这一问题。

作者分析了564例接受放疗或化疗的SCCOP患者的HPV16状态以及3个TGFβ1亚型多态性。使用单因素和多因素模型评估3个亚型多态性与患者生存之间的关系。研究结果表明,85%的患者为HPV阳性SCCOP。TGFβ1 rs1982073与生存显着相关,而TGFβ1 rs1800469和TGFβ1rs1800471无此效果。携带TGFβ1 rs1982073 CT/CC亚型的患者总生存,疾病特异性生存,无病生存均优于纯合TT亚型患者。此外,这些亚型与总死亡,疾病死亡及复发风险减少5倍有关。根据肿瘤HPV状态进行分层分析表明,TGFβ1 rs1982073对生存的显着影响仅局限于SCCOP患者。作者还进一步研究了这些变异的功能相关性。

文章最后认为,TGFβ1 rs1982073多态性在SCCOP患者预后中起到了显着作用,尤其是接受放化疗的HPV16阳性SCCOP患者。需要样本量更大的前瞻性研究验证这些发现。

原始出处:
Ye Tao,Erich M.Sturgis,et al.TGFβ1Genetic Variants Predict Clinical Outcomes of HPV-Positive Oropharyngeal Cancer Patients after Definitive Radiotherapy.CLIN CANCER RES.May 2018 doi:10.1158/1078-0432.CCR-17-1904

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    2018-11-15 changhe713
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    2019-04-04 yuanming7
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586106, encodeId=7c2e158610690, content=<a href='/topic/show?id=38f8622191b' target=_blank style='color:#2F92EE;'>#根治#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62219, encryptionId=38f8622191b, topicName=根治)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26d917348678, createdName=jeanqiuqiu, createdTime=Sun May 20 13:03:00 CST 2018, time=2018-05-20, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2035867, encodeId=67f2203586e74, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Thu Nov 15 01:03:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035806, encodeId=9413203580699, content=<a href='/topic/show?id=3b891e356fc' target=_blank style='color:#2F92EE;'>#TGFβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17356, encryptionId=3b891e356fc, topicName=TGFβ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, 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href='/topic/show?id=40f2381e4a6' target=_blank style='color:#2F92EE;'>#口咽癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38174, encryptionId=40f2381e4a6, topicName=口咽癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun May 20 13:03:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551031, encodeId=3d3f15510312a, content=<a href='/topic/show?id=3d0c62229ee' target=_blank style='color:#2F92EE;'>#根治性放疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62229, encryptionId=3d0c62229ee, topicName=根治性放疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b2314156496, createdName=okhuali, createdTime=Sun May 20 13:03:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586106, encodeId=7c2e158610690, content=<a href='/topic/show?id=38f8622191b' target=_blank style='color:#2F92EE;'>#根治#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62219, encryptionId=38f8622191b, topicName=根治)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26d917348678, createdName=jeanqiuqiu, createdTime=Sun May 20 13:03:00 CST 2018, time=2018-05-20, status=1, ipAttribution=)]
    2018-05-30 yangeasy
  6. [GetPortalCommentsPageByObjectIdResponse(id=2035867, encodeId=67f2203586e74, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Thu Nov 15 01:03:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035806, encodeId=9413203580699, content=<a href='/topic/show?id=3b891e356fc' target=_blank style='color:#2F92EE;'>#TGFβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17356, encryptionId=3b891e356fc, topicName=TGFβ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, 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  7. 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    2018-05-20 jeanqiuqiu

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高危人乳头瘤病毒(HR-HPV)感染会导致一小组口咽癌(OPSCC)亚群的发生,但它们对治疗的反应较好。然而,对于归因于HR-HPV癌症的普遍可接受的界定还未出现。

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近日美国疾病预防控制中心(CDC)发布的数据显示,从2008年到2012年,在美国每年大约有39000例HPV相关的癌症被诊断。近29000例HPV相关癌症可以通过接种HPV疫苗进行预防。这句话里有几个需要弄明白的信息,什么HPV?与HPV相关的癌症有哪些?最后的关键肯定是如何去预防。对HPV做个简单介绍:人乳头瘤病毒( human papillomavirus,HPV) 是一组嗜上皮组织双链